Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

Research output: Contribution to journalJournal articleResearchpeer-review

337 Citations (Scopus)

Abstract

There is considerable interest in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide range of human pathologies. This has been sparked by rapid developments in our understanding of the basic biochemistry of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of biomarkers that can be used damage induced by these oxidants in vivo, and the recent identification of a number of compounds that show promise as inhibitors of these enzymes. Such compounds offer the possibility of modulating damage in a number of human pathologies. This reviews recent developments in our understanding of the biochemistry of myeloperoxidase, the oxidants that this enzyme generates, and the use of inhibitors to inhibit such damage.

Original languageEnglish
JournalJournal of Clinical Biochemistry and Nutrition
Volume48
Issue number1
Pages (from-to)8-19
Number of pages12
ISSN0912-0009
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

Cite this