Abstract
Objectives
To estimate dementia risk for persons diagnosed with Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), which serve as a human chronic inflammation model.
Methods
We identified 9895 individuals in Denmark newly diagnosed with MPNs from 1995 to 2017; matched them 10:1 by age and sex with a general population cohort of 95 770 individuals; and followed them until dementia identification, death, emigration, or December 31, 2018. We applied a Cox proportional-hazards regression model to estimate the cause-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for dementia. We included control diseases, like chronic lymphocytic leukemia (CLL), which is not characterized by chronic inflammation.
Results
Patients with MPNs showed a 1.15-fold (95% CI: 1.04–1.27) increased incidence of dementia compared with members of the general population. Associations were stronger for men with MPNs (HR: 1.40, 95% CI: 1.19–1.63) than for women (HR: 1.02, 95% CI: 0.89–1.15). Patients with CLL showed a decreased dementia incidence (HR: 0.81, 95% CI: 0.72–0.90). The findings for CLL could be explained by depletion-of-susceptibles bias, suggesting that the findings for MPNs were underestimated by a similar bias.
Conclusions
The findings support MPNs as risk factors for dementia and the role of chronic inflammation in dementia development.
To estimate dementia risk for persons diagnosed with Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), which serve as a human chronic inflammation model.
Methods
We identified 9895 individuals in Denmark newly diagnosed with MPNs from 1995 to 2017; matched them 10:1 by age and sex with a general population cohort of 95 770 individuals; and followed them until dementia identification, death, emigration, or December 31, 2018. We applied a Cox proportional-hazards regression model to estimate the cause-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for dementia. We included control diseases, like chronic lymphocytic leukemia (CLL), which is not characterized by chronic inflammation.
Results
Patients with MPNs showed a 1.15-fold (95% CI: 1.04–1.27) increased incidence of dementia compared with members of the general population. Associations were stronger for men with MPNs (HR: 1.40, 95% CI: 1.19–1.63) than for women (HR: 1.02, 95% CI: 0.89–1.15). Patients with CLL showed a decreased dementia incidence (HR: 0.81, 95% CI: 0.72–0.90). The findings for CLL could be explained by depletion-of-susceptibles bias, suggesting that the findings for MPNs were underestimated by a similar bias.
Conclusions
The findings support MPNs as risk factors for dementia and the role of chronic inflammation in dementia development.
| Original language | English |
|---|---|
| Book series | European Journal of Haematology |
| Number of pages | 12 |
| ISSN | 0902-4441 |
| DOIs | |
| Publication status | E-pub ahead of print - 16 Sep 2024 |