Neocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals

Anjali Sankar*, Simon C. Ziersen, Brice Ozenne, Vibeke H. Dam, Emily E. Beaman, Lars V. Kessing, Patrick. M. Fisher, Esben Budtz-jørgensen, Gitte M. Knudsen, Kamilla W. Miskowiak, Vibe G. Frokjaer

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The serotonin 2A receptor (5-HT2AR) and personality trait neuroticism are implicated in the pathophysiology of depression and represent potential targets for prevention and treatment. Here we evaluate whether 5-HT2AR and neuroticism in healthy individuals are related to the risk of developing a future depressive episode by utilizing a large 5-HT2AR molecular-imaging cohort comprising 131 healthy individuals who underwent molecular brain imaging and neuroticism assessments and up to 19 years of data on future depression diagnosis from the Danish Registers. Using cause-specific Cox regression analysis, we found that neocortical 5-HT2AR binding coupled with the inward-directed facets of neuroticism elevated the risk of depression. The risk was greatest in individuals with both high 5-HT2AR binding and high neuroticism. Our data provide novel insights into the risk of depression and support the evaluation of clinical strategies that target 5-HT2AR, such as psychedelics, in conjunction with psychotherapy that addresses personality-based risk factors.
Original languageEnglish
JournalNature Mental Health
Volume2
Issue number10
Pages (from-to)1231-1238
Number of pages8
DOIs
Publication statusPublished - 2024

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