TY - JOUR
T1 - Neonatal levels of cytokines and risk of autism spectrum disorders
T2 - An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank
AU - Abdallah, Morsi
AU - Larsen, Nanna
AU - Mortensen, Erik L
AU - Atladóttir, Hjördis Ó
AU - Nørgaard-Pedersen, Bent
AU - Bonefeld-Jørgensen, Eva Cecilie
AU - Grove, Jakob
AU - Hougaard, David M
N1 - Copyright © 2012 Elsevier B.V. All rights reserved.
PY - 2012
Y1 - 2012
N2 - The aim of the study was to analyze cytokine profiles in neonatal dried blood samples (n-DBSS) retrieved from The Danish Newborn Screening Biobank of children developing Autism Spectrum Disorders (ASD) later in life and controls. Samples of 359 ASD cases and 741 controls were analyzed using Luminex xMAP technology and clinical data were retrieved from nationwide registers. Findings showed that children developing ASD were more likely to have decreased levels of both T helper-1(Th-1)-like cytokines (i.e. IFN-¿) and Th-2like cytokines (i.e. IL-4, IL-10) which may suggest a depressed or hypoactive immune cell activity during neonatal period in ASD.
AB - The aim of the study was to analyze cytokine profiles in neonatal dried blood samples (n-DBSS) retrieved from The Danish Newborn Screening Biobank of children developing Autism Spectrum Disorders (ASD) later in life and controls. Samples of 359 ASD cases and 741 controls were analyzed using Luminex xMAP technology and clinical data were retrieved from nationwide registers. Findings showed that children developing ASD were more likely to have decreased levels of both T helper-1(Th-1)-like cytokines (i.e. IFN-¿) and Th-2like cytokines (i.e. IL-4, IL-10) which may suggest a depressed or hypoactive immune cell activity during neonatal period in ASD.
U2 - 10.1016/j.jneuroim.2012.07.013
DO - 10.1016/j.jneuroim.2012.07.013
M3 - Journal article
C2 - 22917523
VL - 252
SP - 75
EP - 82
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -