Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools

Jesper Kelsen; Marianne Larsen; Jens Christian H. Sørensen; Arne Møller; Jørgen Frøkiaer; Søren Nielsen; Jens Randel Nyengaard; Jens D Mikkelsen; Lars Christian B Rønn

doi:10.1186/2040-7378-2-8

Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools

Jesper Kelsen, Marianne Larsen, Jens Christian H. Sørensen, Arne Møller, Jørgen Frøkiaer, Søren Nielsen, Jens Randel Nyengaard, Jens D Mikkelsen, Lars Christian B Rønn

Department of Clinical Medicine

Research output: Contribution to journal › Journal article › Research › peer-review

7 Citations (Scopus)

Abstract

We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo.

Original language	English
Journal	Experimental & translational stroke medicine
Volume	2
Pages (from-to)	8
DOIs	https://doi.org/10.1186/2040-7378-2-8
Publication status	Published - 1 Jan 2010

Access to Document

10.1186/2040-7378-2-8

Library access?

Check availability at the Royal Danish Library

Cite this

Kelsen, J., Larsen, M., Sørensen, J. C. H., Møller, A., Frøkiaer, J., Nielsen, S., Nyengaard, J. R., Mikkelsen, J. D., & Rønn, L. C. B. (2010). Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools. Experimental & translational stroke medicine, 2, 8. https://doi.org/10.1186/2040-7378-2-8

Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools. / Kelsen, Jesper; Larsen, Marianne; Sørensen, Jens Christian H. et al.
In: Experimental & translational stroke medicine, Vol. 2, 01.01.2010, p. 8.

Research output: Contribution to journal › Journal article › Research › peer-review

Kelsen, J, Larsen, M, Sørensen, JCH, Møller, A, Frøkiaer, J, Nielsen, S, Nyengaard, JR, Mikkelsen, JD & Rønn, LCB 2010, 'Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools', Experimental & translational stroke medicine, vol. 2, pp. 8. https://doi.org/10.1186/2040-7378-2-8

@article{e4bb73ef956545389641035a6e93baee,

title = "Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools",

abstract = "We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo.",

author = "Jesper Kelsen and Marianne Larsen and S{\o}rensen, {Jens Christian H.} and Arne M{\o}ller and J{\o}rgen Fr{\o}kiaer and S{\o}ren Nielsen and Nyengaard, {Jens Randel} and Mikkelsen, {Jens D} and R{\o}nn, {Lars Christian B}",

year = "2010",

month = jan,

day = "1",

doi = "10.1186/2040-7378-2-8",

language = "English",

volume = "2",

pages = "8",

journal = "Experimental & translational stroke medicine",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools

AU - Kelsen, Jesper

AU - Larsen, Marianne

AU - Sørensen, Jens Christian H.

AU - Møller, Arne

AU - Frøkiaer, Jørgen

AU - Nielsen, Søren

AU - Nyengaard, Jens Randel

AU - Mikkelsen, Jens D

AU - Rønn, Lars Christian B

PY - 2010/1/1

Y1 - 2010/1/1

N2 - We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo.

AB - We are currently investigating microglial activation and neuronal precursor cell (NPC) proliferation after transient middle cerebral artery occlusion (tMCAo) in rats. This study aimed: (1) to investigate differences in hippocampal NPC proliferation in outbred male spontaneously hypertensive rats (SHRs) and Sprague-Dawley rats (SDs) one week after tMCAo; (2) to present the practical use of the optical fractionator and 2D nucleator in stereological brain tissue analyses; and (3) to report our experiences with an intraluminal tMCAo model where the occluding filament is advanced 22 mm beyond the carotid bifurcation and the common carotid artery is clamped during tMCAo.

U2 - 10.1186/2040-7378-2-8

DO - 10.1186/2040-7378-2-8

M3 - Journal article

VL - 2

SP - 8

JO - Experimental & translational stroke medicine

JF - Experimental & translational stroke medicine

ER -