No association between DGKH and bipolar disorder in a Scandinavian case-control sample

Martin Tesli, Anna Kähler, Bettina Andreassen, Thomas Werge, Ole Mors, Erling Mellerup, Pernille Koefoed, Ingrid Melle, Gunnar Morken, Katrine Wirgenes, Ole Andreassen, Srdjan Djurovic, Martin Tesli, Anna K Kähler, Bettina Kulle Andreassen, Thomas Werge, Ole Mors, Erling Mellerup, Pernille Koefoed, Ingrid MelleGunnar Morken, Katrine V Wirgenes, Ole A Andreassen, Srdjan Djurovic

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21 Citations (Scopus)

Abstract

Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.
Original languageEnglish
JournalPsychiatric Genetics
Volume19
Issue number5
Pages (from-to)269-72
Number of pages3
ISSN0955-8829
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords: Adult; Bipolar Disorder; Case-Control Studies; Diacylglycerol Kinase; European Continental Ancestry Group; Female; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Scandinavia

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