Abstract
| Original language | English |
|---|---|
| Journal | Diabetes |
| Volume | 61 |
| Issue number | 5 |
| Pages (from-to) | 1291-6 |
| Number of pages | 6 |
| ISSN | 0046-0192 |
| DOIs | |
| Publication status | Published - 2012 |
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No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. / Scott, Robert A; Chu, Audrey Y; Grarup, Niels; Manning, Alisa K; Hivert, Marie-France; Shungin, Dmitry; Tönjes, Anke; Yesupriya, Ajay; Barnes, Daniel; Bouatia-Naji, Nabila; Glazer, Nicole L; Jackson, Anne U; Kutalik, Zoltán; Lagou, Vasiliki; Marek, Diana; Rasmussen-Torvik, Laura J; Stringham, Heather M; Tanaka, Toshiko; Aadahl, Mette; Arking, Dan E; Bergmann, Sven; Boerwinkle, Eric; Bonnycastle, Lori L; Bornstein, Stefan R; Brunner, Eric; Bumpstead, Suzannah J; Brage, Soren; Carlson, Olga D; Chen, Han; Chen, Yii-Der Ida; Chines, Peter S; Collins, Francis S; Couper, David J; Dennison, Elaine M; Dowling, Nicole F; Egan, Josephine S; Ekelund, Ulf; Erdos, Michael R; Forouhi, Nita G; Fox, Caroline S; Goodarzi, Mark O; Grässler, Jürgen; Gustafsson, Stefan; Hallmans, Göran; Hansen, Torben; Hingorani, Aroon; Holloway, John W; Hu, Frank B; Isomaa, Bo; Jameson, Karen A; Johansson, Ingegerd; Jonsson, Anna Elisabet; Jørgensen, Torben; Kivimaki, Mika; Kovacs, Peter; Kumari, Meena; Kuusisto, Johanna; Laakso, Markku; Lecoeur, Cécile; Lévy-Marchal, Claire; Li, Guo; Loos, Ruth J F; Lyssenko, Valeri; Marmot, Michael; Marques-Vidal, Pedro; Morken, Mario A; Müller, Gabriele; North, Kari E; Pankow, James S; Payne, Felicity; Prokopenko, Inga; Psaty, Bruce M; Renström, Frida; Rice, Ken; Rotter, Jerome I; Rybin, Denis; Sandholt, Camilla H; Sayer, Avan A; Shrader, Peter; Schwarz, Peter E H; Siscovick, David S; Stancáková, Alena; Stumvoll, Michael; Teslovich, Tanya M; Waeber, Gérard; Williams, Gordon H; Witte, Daniel R; Wood, Andrew R; Xie, Weijia; Boehnke, Michael; Cooper, Cyrus; Ferrucci, Luigi; Froguel, Philippe; Groop, Leif; Kao, W H Linda; Vollenweider, Peter; Walker, Mark; Watanabe, Richard M; Pedersen, Oluf; Meigs, James B; Ingelsson, Erik; Barroso, Inês; Florez, Jose C; Franks, Paul W; Dupuis, Josée; Wareham, Nicholas J; Langenberg, Claudia.
In: Diabetes, Vol. 61, No. 5, 2012, p. 1291-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
AU - Scott, Robert A
AU - Chu, Audrey Y
AU - Grarup, Niels
AU - Manning, Alisa K
AU - Hivert, Marie-France
AU - Shungin, Dmitry
AU - Tönjes, Anke
AU - Yesupriya, Ajay
AU - Barnes, Daniel
AU - Bouatia-Naji, Nabila
AU - Glazer, Nicole L
AU - Jackson, Anne U
AU - Kutalik, Zoltán
AU - Lagou, Vasiliki
AU - Marek, Diana
AU - Rasmussen-Torvik, Laura J
AU - Stringham, Heather M
AU - Tanaka, Toshiko
AU - Aadahl, Mette
AU - Arking, Dan E
AU - Bergmann, Sven
AU - Boerwinkle, Eric
AU - Bonnycastle, Lori L
AU - Bornstein, Stefan R
AU - Brunner, Eric
AU - Bumpstead, Suzannah J
AU - Brage, Soren
AU - Carlson, Olga D
AU - Chen, Han
AU - Chen, Yii-Der Ida
AU - Chines, Peter S
AU - Collins, Francis S
AU - Couper, David J
AU - Dennison, Elaine M
AU - Dowling, Nicole F
AU - Egan, Josephine S
AU - Ekelund, Ulf
AU - Erdos, Michael R
AU - Forouhi, Nita G
AU - Fox, Caroline S
AU - Goodarzi, Mark O
AU - Grässler, Jürgen
AU - Gustafsson, Stefan
AU - Hallmans, Göran
AU - Hansen, Torben
AU - Hingorani, Aroon
AU - Holloway, John W
AU - Hu, Frank B
AU - Isomaa, Bo
AU - Jameson, Karen A
AU - Johansson, Ingegerd
AU - Jonsson, Anna Elisabet
AU - Jørgensen, Torben
AU - Kivimaki, Mika
AU - Kovacs, Peter
AU - Kumari, Meena
AU - Kuusisto, Johanna
AU - Laakso, Markku
AU - Lecoeur, Cécile
AU - Lévy-Marchal, Claire
AU - Li, Guo
AU - Loos, Ruth J F
AU - Lyssenko, Valeri
AU - Marmot, Michael
AU - Marques-Vidal, Pedro
AU - Morken, Mario A
AU - Müller, Gabriele
AU - North, Kari E
AU - Pankow, James S
AU - Payne, Felicity
AU - Prokopenko, Inga
AU - Psaty, Bruce M
AU - Renström, Frida
AU - Rice, Ken
AU - Rotter, Jerome I
AU - Rybin, Denis
AU - Sandholt, Camilla H
AU - Sayer, Avan A
AU - Shrader, Peter
AU - Schwarz, Peter E H
AU - Siscovick, David S
AU - Stancáková, Alena
AU - Stumvoll, Michael
AU - Teslovich, Tanya M
AU - Waeber, Gérard
AU - Williams, Gordon H
AU - Witte, Daniel R
AU - Wood, Andrew R
AU - Xie, Weijia
AU - Boehnke, Michael
AU - Cooper, Cyrus
AU - Ferrucci, Luigi
AU - Froguel, Philippe
AU - Groop, Leif
AU - Kao, W H Linda
AU - Vollenweider, Peter
AU - Walker, Mark
AU - Watanabe, Richard M
AU - Pedersen, Oluf
AU - Meigs, James B
AU - Ingelsson, Erik
AU - Barroso, Inês
AU - Florez, Jose C
AU - Franks, Paul W
AU - Dupuis, Josée
AU - Wareham, Nicholas J
AU - Langenberg, Claudia
PY - 2012
Y1 - 2012
N2 - Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (ß = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (ß = 0.06-0.12 mmol/allele, P = 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P = 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
AB - Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (ß = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (ß = 0.06-0.12 mmol/allele, P = 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P = 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
U2 - 10.2337/db11-0973
DO - 10.2337/db11-0973
M3 - Journal article
C2 - 22415877
VL - 61
SP - 1291
EP - 1296
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 5
ER -