Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

Shuncong Zhong; Yao Chun Shen; Louise Ho; Robert K. May; J. Axel Zeitler; Mike Evans; Philip F. Taday; Michael Pepper; Thomas Rades; Keith C. Gordon; Ronny Mller; Peter Kleinebudde

doi:10.1016/j.optlaseng.2010.11.003

Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

Shuncong Zhong, Yao Chun Shen^*, Louise Ho, Robert K. May, J. Axel Zeitler, Mike Evans, Philip F. Taday, Michael Pepper, Thomas Rades, Keith C. Gordon, Ronny Mller, Peter Kleinebudde

^*Corresponding author for this work

Solid State Pharmaceutics

Research output: Contribution to journal › Journal article › Research › peer-review

124 Citations (Scopus)

Abstract

Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non-destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10140 μm. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 μm, and is capable of quantifying very thin coatings in the range of 1060 μm. The upper limit of 60 μm within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.51.0 μm. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40140 μm and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings.

Original language	English
Journal	Optics and Lasers in Engineering
Volume	49
Issue number	3
Pages (from-to)	361-365
Number of pages	5
ISSN	0143-8166
DOIs	https://doi.org/10.1016/j.optlaseng.2010.11.003
Publication status	Published - Mar 2011

Bibliographical note

Funding Information:
The authors would like to acknowledge the financial support from UK Technology Strategy Board ( AB293H ). S. Zhong would like to thank Fuzhou University Research Fund, Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, P.R. China, and National Natural Science Foundation of China ( 51005077 ).

Keywords

Non-destructive testing
Optical coherence tomography
Tablet coating thickness
Terahertz pulsed imaging

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10.1016/j.optlaseng.2010.11.003

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Zhong, S., Shen, Y. C., Ho, L., May, R. K., Zeitler, J. A., Evans, M., Taday, P. F., Pepper, M., Rades, T., Gordon, K. C., Mller, R., & Kleinebudde, P. (2011). Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography. Optics and Lasers in Engineering, 49(3), 361-365. https://doi.org/10.1016/j.optlaseng.2010.11.003

Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography. / Zhong, Shuncong; Shen, Yao Chun; Ho, Louise; May, Robert K.; Zeitler, J. Axel; Evans, Mike; Taday, Philip F.; Pepper, Michael; Rades, Thomas; Gordon, Keith C.; Mller, Ronny; Kleinebudde, Peter.

In: Optics and Lasers in Engineering, Vol. 49, No. 3, 03.2011, p. 361-365.

Research output: Contribution to journal › Journal article › Research › peer-review

Zhong, S, Shen, YC, Ho, L, May, RK, Zeitler, JA, Evans, M, Taday, PF, Pepper, M, Rades, T, Gordon, KC, Mller, R & Kleinebudde, P 2011, 'Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography', Optics and Lasers in Engineering, vol. 49, no. 3, pp. 361-365. https://doi.org/10.1016/j.optlaseng.2010.11.003

Zhong, Shuncong ; Shen, Yao Chun ; Ho, Louise ; May, Robert K. ; Zeitler, J. Axel ; Evans, Mike ; Taday, Philip F. ; Pepper, Michael ; Rades, Thomas ; Gordon, Keith C. ; Mller, Ronny ; Kleinebudde, Peter. / Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography. In: Optics and Lasers in Engineering. 2011 ; Vol. 49, No. 3. pp. 361-365.

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abstract = "Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non-destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10140 μm. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 μm, and is capable of quantifying very thin coatings in the range of 1060 μm. The upper limit of 60 μm within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.51.0 μm. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40140 μm and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings.",

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note = "Funding Information: The authors would like to acknowledge the financial support from UK Technology Strategy Board ( AB293H ). S. Zhong would like to thank Fuzhou University Research Fund, Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, P.R. China, and National Natural Science Foundation of China ( 51005077 ).",

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AU - Zhong, Shuncong

AU - Shen, Yao Chun

AU - Ho, Louise

AU - May, Robert K.

AU - Zeitler, J. Axel

AU - Evans, Mike

AU - Taday, Philip F.

AU - Pepper, Michael

AU - Rades, Thomas

AU - Gordon, Keith C.

AU - Mller, Ronny

AU - Kleinebudde, Peter

N1 - Funding Information: The authors would like to acknowledge the financial support from UK Technology Strategy Board ( AB293H ). S. Zhong would like to thank Fuzhou University Research Fund, Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry, P.R. China, and National Natural Science Foundation of China ( 51005077 ).

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N2 - Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non-destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10140 μm. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 μm, and is capable of quantifying very thin coatings in the range of 1060 μm. The upper limit of 60 μm within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.51.0 μm. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40140 μm and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings.

AB - Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI) are two powerful techniques allowing high quality cross-sectional images from within scattering media to be obtained non-destructively. In this paper, we report experimental results of using OCT and TPI for quantitatively characterizing pharmaceutical tablet coatings in the thickness range of 10140 μm. We found that the spectral OCT system developed in-house has an axial resolution of 0.9 μm, and is capable of quantifying very thin coatings in the range of 1060 μm. The upper limit of 60 μm within the tablet coating and core is owed to the strong scattering of OCT light, which has relatively short wavelengths in the range of 0.51.0 μm. On the other hand, TPI utilizes terahertz radiation that has substantially long wavelengths in the range of hundreds of microns, and thus is less prone to the scattering problem. Consequently TPI has been demonstrated to be able to quantify thicker coatings in the range of 40140 μm and beyond. We concluded that OCT and TPI are two complementary analytical techniques for non-destructive and quantitative characterization of pharmaceutical tablet coatings.

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Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

Abstract

Bibliographical note

Keywords

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