Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin

Christian Gytz Ammitzbøll; Troels Rønn Kjær; Rudi Nora Steffensen; Kristian Stengaard-Pedersen; Hans Jørgen Nielsen; Steffen Thiel; Martin Bøgsted; Jens Christian Jensenius

doi:10.1371/journal.pone.0050585

Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin

Christian Gytz Ammitzbøll, Troels Rønn Kjær, Rudi Nora Steffensen, Kristian Stengaard-Pedersen, Hans Jørgen Nielsen, Steffen Thiel, Martin Bøgsted, Jens Christian Jensenius

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Abstract

The innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells. One such pattern-recognition molecule is M-ficolin, which is capable of activating the complement system through the lectin pathway. The lectin pathway is multifaceted with activities spanning from complement activation to coagulation, autoimmunity, ischemia-reperfusion injury and embryogenesis. Our aim was to explore associations between SNPs in FCN1, encoding M-ficolin and corresponding protein concentrations, and the impact of non-synonymous SNPs on protein function.

Original language	English
Journal	P L o S One
Volume	7
Issue number	11
Pages (from-to)	e50585
Number of pages	10
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0050585
Publication status	Published - 2012

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10.1371/journal.pone.0050585

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Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin. / Ammitzbøll, Christian Gytz; Kjær, Troels Rønn; Steffensen, Rudi Nora; Stengaard-Pedersen, Kristian; Nielsen, Hans Jørgen; Thiel, Steffen; Bøgsted, Martin; Jensenius, Jens Christian.

In: P L o S One, Vol. 7, No. 11, 2012, p. e50585.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Steffensen, Rudi Nora

AU - Stengaard-Pedersen, Kristian

AU - Nielsen, Hans Jørgen

AU - Thiel, Steffen

AU - Bøgsted, Martin

AU - Jensenius, Jens Christian

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