Noninvasive blood tests for fetal development predict gestational age and preterm delivery

Thuy T. M. Ngo; Mira N. Moufarrej; Marie-Louise H. Rasmussen; Joan Camunas-Soler; Wenying Pan; Jennifer Okamoto; Norma F. Neff; Keli Liu; Ronald J. Wong; Katheryne Downes; Robert Tibshirani; Gary M. Shaw; Line Skotte; David K. Stevenson; Joseph R. Biggio; Michal A. Elovitz; Mads Melbye; Stephen R. Quake

doi:10.1126/science.aar3819

Noninvasive blood tests for fetal development predict gestational age and preterm delivery

Thuy T. M. Ngo, Mira N. Moufarrej, Marie-Louise H. Rasmussen, Joan Camunas-Soler, Wenying Pan, Jennifer Okamoto, Norma F. Neff, Keli Liu, Ronald J. Wong, Katheryne Downes, Robert Tibshirani, Gary M. Shaw, Line Skotte, David K. Stevenson, Joseph R. Biggio, Michal A. Elovitz, Mads Melbye^*, Stephen R. Quake

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

181 Citations (Scopus)

21 Downloads (Pure)

Abstract

Noninvasive blood tests that provide information about fetal development and gestational age could potentially improve prenatal care. Ultrasound, the current gold standard, is not always affordable in low-resource settings and does not predict spontaneous preterm birth, a leading cause of infant death. In a pilot study of 31 healthy pregnant women, we found that measurement of nine cell-free RNA (cfRNA) transcripts in maternal blood predicted gestational age with comparable accuracy to ultrasound but at substantially lower cost. In a related study of 38 women (25 full-term and 13 preterm deliveries), all at elevated risk of delivering preterm, we identified seven cfRNA transcripts that accurately classified women who delivered preterm up to 2 months in advance of labor. These tests hold promise for prenatal care in both the developed and developing worlds, although they require validation in larger, blinded clinical trials.

Original language	English
Journal	Science
Volume	360
Issue number	6393
Pages (from-to)	1133-1136
Number of pages	4
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.aar3819
Publication status	Published - 2018
Externally published	Yes

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Noninvasive blood tests for fetal development predict gestational age and preterm deliveryFinal published version, 466 KBLicence: CC BY

Cite this

Ngo, T. T. M., Moufarrej, M. N., Rasmussen, M-L. H., Camunas-Soler, J., Pan, W., Okamoto, J., Neff, N. F., Liu, K., Wong, R. J., Downes, K., Tibshirani, R., Shaw, G. M., Skotte, L., Stevenson, D. K., Biggio, J. R., Elovitz, M. A., Melbye, M., & Quake, S. R. (2018). Noninvasive blood tests for fetal development predict gestational age and preterm delivery. Science, 360(6393), 1133-1136. https://doi.org/10.1126/science.aar3819

Noninvasive blood tests for fetal development predict gestational age and preterm delivery. / Ngo, Thuy T. M.; Moufarrej, Mira N.; Rasmussen, Marie-Louise H.; Camunas-Soler, Joan; Pan, Wenying; Okamoto, Jennifer; Neff, Norma F.; Liu, Keli; Wong, Ronald J.; Downes, Katheryne; Tibshirani, Robert; Shaw, Gary M.; Skotte, Line; Stevenson, David K.; Biggio, Joseph R.; Elovitz, Michal A.; Melbye, Mads; Quake, Stephen R.

In: Science, Vol. 360, No. 6393, 2018, p. 1133-1136.

Research output: Contribution to journal › Journal article › Research › peer-review

Ngo, TTM, Moufarrej, MN, Rasmussen, M-LH, Camunas-Soler, J, Pan, W, Okamoto, J, Neff, NF, Liu, K, Wong, RJ, Downes, K, Tibshirani, R, Shaw, GM, Skotte, L, Stevenson, DK, Biggio, JR, Elovitz, MA, Melbye, M & Quake, SR 2018, 'Noninvasive blood tests for fetal development predict gestational age and preterm delivery', Science, vol. 360, no. 6393, pp. 1133-1136. https://doi.org/10.1126/science.aar3819

Ngo, Thuy T. M. ; Moufarrej, Mira N. ; Rasmussen, Marie-Louise H. ; Camunas-Soler, Joan ; Pan, Wenying ; Okamoto, Jennifer ; Neff, Norma F. ; Liu, Keli ; Wong, Ronald J. ; Downes, Katheryne ; Tibshirani, Robert ; Shaw, Gary M. ; Skotte, Line ; Stevenson, David K. ; Biggio, Joseph R. ; Elovitz, Michal A. ; Melbye, Mads ; Quake, Stephen R. / Noninvasive blood tests for fetal development predict gestational age and preterm delivery. In: Science. 2018 ; Vol. 360, No. 6393. pp. 1133-1136.

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title = "Noninvasive blood tests for fetal development predict gestational age and preterm delivery",

abstract = "Noninvasive blood tests that provide information about fetal development and gestational age could potentially improve prenatal care. Ultrasound, the current gold standard, is not always affordable in low-resource settings and does not predict spontaneous preterm birth, a leading cause of infant death. In a pilot study of 31 healthy pregnant women, we found that measurement of nine cell-free RNA (cfRNA) transcripts in maternal blood predicted gestational age with comparable accuracy to ultrasound but at substantially lower cost. In a related study of 38 women (25 full-term and 13 preterm deliveries), all at elevated risk of delivering preterm, we identified seven cfRNA transcripts that accurately classified women who delivered preterm up to 2 months in advance of labor. These tests hold promise for prenatal care in both the developed and developing worlds, although they require validation in larger, blinded clinical trials.",

author = "Ngo, {Thuy T. M.} and Moufarrej, {Mira N.} and Rasmussen, {Marie-Louise H.} and Joan Camunas-Soler and Wenying Pan and Jennifer Okamoto and Neff, {Norma F.} and Keli Liu and Wong, {Ronald J.} and Katheryne Downes and Robert Tibshirani and Shaw, {Gary M.} and Line Skotte and Stevenson, {David K.} and Biggio, {Joseph R.} and Elovitz, {Michal A.} and Mads Melbye and Quake, {Stephen R.}",

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AU - Ngo, Thuy T. M.

AU - Moufarrej, Mira N.

AU - Rasmussen, Marie-Louise H.

AU - Camunas-Soler, Joan

AU - Pan, Wenying

AU - Okamoto, Jennifer

AU - Neff, Norma F.

AU - Liu, Keli

AU - Wong, Ronald J.

AU - Downes, Katheryne

AU - Tibshirani, Robert

AU - Shaw, Gary M.

AU - Skotte, Line

AU - Stevenson, David K.

AU - Biggio, Joseph R.

AU - Elovitz, Michal A.

AU - Melbye, Mads

AU - Quake, Stephen R.

PY - 2018

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AB - Noninvasive blood tests that provide information about fetal development and gestational age could potentially improve prenatal care. Ultrasound, the current gold standard, is not always affordable in low-resource settings and does not predict spontaneous preterm birth, a leading cause of infant death. In a pilot study of 31 healthy pregnant women, we found that measurement of nine cell-free RNA (cfRNA) transcripts in maternal blood predicted gestational age with comparable accuracy to ultrasound but at substantially lower cost. In a related study of 38 women (25 full-term and 13 preterm deliveries), all at elevated risk of delivering preterm, we identified seven cfRNA transcripts that accurately classified women who delivered preterm up to 2 months in advance of labor. These tests hold promise for prenatal care in both the developed and developing worlds, although they require validation in larger, blinded clinical trials.

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