Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Zari Dastani; Marie-France Hivert; Nicholas Timpson; John R B Perry; Xin Yuan; Robert A Scott; Peter Henneman; Iris M Heid; Jorge R Kizer; Leo-Pekka Lyytikäinen; Christian Fuchsberger; Toshiko Tanaka; Andrew P Morris; Kerrin Small; Aaron Isaacs; Marian Beekman; Stefan Coassin; Kurt Lohman; Lu Qi; Stavroula Kanoni; James S Pankow; Hae-Won Uh; Ying Wu; Aurelian Bidulescu; Laura J Rasmussen-Torvik; Celia M T Greenwood; Martin Ladouceur; Jonna Grimsby; Alisa K Manning; Ching-Ti Liu; Jaspal Kooner; Vincent E Mooser; Peter Vollenweider; Karen A Kapur; John Chambers; Nicholas J Wareham; Claudia Langenberg; Rune Frants; Ko Willems-Vandijk; Ben A Oostra; Sara M Willems; Claudia Lamina; Thomas W Winkler; Niels Grarup; Torben Jørgensen; Thomas Sparsø; Torben Hansen; Oluf Pedersen; Fredrik Karpe; Kirsten O Kyvik; DIAGRAM+ Consortium

doi:10.1371/journal.pgen.1002607

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R B Perry, Xin Yuan, Robert A Scott, Peter Henneman, Iris M Heid, Jorge R Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger, Toshiko Tanaka, Andrew P Morris, Kerrin Small, Aaron Isaacs, Marian Beekman, Stefan Coassin, Kurt Lohman, Lu Qi, Stavroula KanoniJames S Pankow, Hae-Won Uh, Ying Wu, Aurelian Bidulescu, Laura J Rasmussen-Torvik, Celia M T Greenwood, Martin Ladouceur, Jonna Grimsby, Alisa K Manning, Ching-Ti Liu, Jaspal Kooner, Vincent E Mooser, Peter Vollenweider, Karen A Kapur, John Chambers, Nicholas J Wareham, Claudia Langenberg, Rune Frants, Ko Willems-Vandijk, Ben A Oostra, Sara M Willems, Claudia Lamina, Thomas W Winkler, Niels Grarup, Torben Jørgensen, Thomas Sparsø, Torben Hansen, Oluf Pedersen, Fredrik Karpe, Kirsten O Kyvik, DIAGRAM+ Consortium

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P¿=¿4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N¿=¿4,232 African Americans, N¿=¿1,776 Asians, and N¿=¿29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p

Original language	English
Journal	P L o S Genetics (Online)
Volume	8
Issue number	3
Pages (from-to)	e1002607
ISSN	1553-7404
DOIs	https://doi.org/10.1371/journal.pgen.1002607
Publication status	Published - 2012

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10.1371/journal.pgen.1002607

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Dastani, Z., Hivert, M-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L-P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., ... DIAGRAM+ Consortium (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. P L o S Genetics (Online), 8(3), e1002607. https://doi.org/10.1371/journal.pgen.1002607

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits : a multi-ethnic meta-analysis of 45,891 individuals. / Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John R B; Yuan, Xin; Scott, Robert A; Henneman, Peter; Heid, Iris M; Kizer, Jorge R; Lyytikäinen, Leo-Pekka; Fuchsberger, Christian; Tanaka, Toshiko; Morris, Andrew P; Small, Kerrin; Isaacs, Aaron; Beekman, Marian; Coassin, Stefan; Lohman, Kurt; Qi, Lu; Kanoni, Stavroula; Pankow, James S; Uh, Hae-Won; Wu, Ying; Bidulescu, Aurelian; Rasmussen-Torvik, Laura J; Greenwood, Celia M T; Ladouceur, Martin; Grimsby, Jonna; Manning, Alisa K; Liu, Ching-Ti; Kooner, Jaspal; Mooser, Vincent E; Vollenweider, Peter; Kapur, Karen A; Chambers, John; Wareham, Nicholas J; Langenberg, Claudia; Frants, Rune; Willems-Vandijk, Ko; Oostra, Ben A; Willems, Sara M; Lamina, Claudia; Winkler, Thomas W; Grarup, Niels; Jørgensen, Torben; Sparsø, Thomas; Hansen, Torben ; Pedersen, Oluf; Karpe, Fredrik; Kyvik, Kirsten O; DIAGRAM+ Consortium.

In: P L o S Genetics (Online), Vol. 8, No. 3, 2012, p. e1002607.

Research output: Contribution to journal › Journal article › Research › peer-review

Dastani, Z, Hivert, M-F, Timpson, N, Perry, JRB, Yuan, X, Scott, RA, Henneman, P, Heid, IM, Kizer, JR, Lyytikäinen, L-P, Fuchsberger, C, Tanaka, T, Morris, AP, Small, K, Isaacs, A, Beekman, M, Coassin, S, Lohman, K, Qi, L, Kanoni, S, Pankow, JS, Uh, H-W, Wu, Y, Bidulescu, A, Rasmussen-Torvik, LJ, Greenwood, CMT, Ladouceur, M, Grimsby, J, Manning, AK, Liu, C-T, Kooner, J, Mooser, VE, Vollenweider, P, Kapur, KA, Chambers, J, Wareham, NJ, Langenberg, C, Frants, R, Willems-Vandijk, K, Oostra, BA, Willems, SM, Lamina, C, Winkler, TW, Grarup, N, Jørgensen, T, Sparsø, T, Hansen, T , Pedersen, O, Karpe, F, Kyvik, KO & DIAGRAM+ Consortium 2012, 'Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals', P L o S Genetics (Online), vol. 8, no. 3, pp. e1002607. https://doi.org/10.1371/journal.pgen.1002607

Dastani, Zari ; Hivert, Marie-France ; Timpson, Nicholas ; Perry, John R B ; Yuan, Xin ; Scott, Robert A ; Henneman, Peter ; Heid, Iris M ; Kizer, Jorge R ; Lyytikäinen, Leo-Pekka ; Fuchsberger, Christian ; Tanaka, Toshiko ; Morris, Andrew P ; Small, Kerrin ; Isaacs, Aaron ; Beekman, Marian ; Coassin, Stefan ; Lohman, Kurt ; Qi, Lu ; Kanoni, Stavroula ; Pankow, James S ; Uh, Hae-Won ; Wu, Ying ; Bidulescu, Aurelian ; Rasmussen-Torvik, Laura J ; Greenwood, Celia M T ; Ladouceur, Martin ; Grimsby, Jonna ; Manning, Alisa K ; Liu, Ching-Ti ; Kooner, Jaspal ; Mooser, Vincent E ; Vollenweider, Peter ; Kapur, Karen A ; Chambers, John ; Wareham, Nicholas J ; Langenberg, Claudia ; Frants, Rune ; Willems-Vandijk, Ko ; Oostra, Ben A ; Willems, Sara M ; Lamina, Claudia ; Winkler, Thomas W ; Grarup, Niels ; Jørgensen, Torben ; Sparsø, Thomas ; Hansen, Torben ; Pedersen, Oluf ; Karpe, Fredrik ; Kyvik, Kirsten O ; DIAGRAM+ Consortium. / Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits : a multi-ethnic meta-analysis of 45,891 individuals. In: P L o S Genetics (Online). 2012 ; Vol. 8, No. 3. pp. e1002607.

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abstract = "Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P¿=¿4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N¿=¿4,232 African Americans, N¿=¿1,776 Asians, and N¿=¿29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p",

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AU - Dastani, Zari

AU - Hivert, Marie-France

AU - Timpson, Nicholas

AU - Perry, John R B

AU - Yuan, Xin

AU - Scott, Robert A

AU - Henneman, Peter

AU - Heid, Iris M

AU - Kizer, Jorge R

AU - Lyytikäinen, Leo-Pekka

AU - Fuchsberger, Christian

AU - Tanaka, Toshiko

AU - Morris, Andrew P

AU - Small, Kerrin

AU - Isaacs, Aaron

AU - Beekman, Marian

AU - Coassin, Stefan

AU - Lohman, Kurt

AU - Qi, Lu

AU - Kanoni, Stavroula

AU - Pankow, James S

AU - Uh, Hae-Won

AU - Wu, Ying

AU - Bidulescu, Aurelian

AU - Rasmussen-Torvik, Laura J

AU - Greenwood, Celia M T

AU - Ladouceur, Martin

AU - Grimsby, Jonna

AU - Manning, Alisa K

AU - Liu, Ching-Ti

AU - Kooner, Jaspal

AU - Mooser, Vincent E

AU - Vollenweider, Peter

AU - Kapur, Karen A

AU - Chambers, John

AU - Wareham, Nicholas J

AU - Langenberg, Claudia

AU - Frants, Rune

AU - Willems-Vandijk, Ko

AU - Oostra, Ben A

AU - Willems, Sara M

AU - Lamina, Claudia

AU - Winkler, Thomas W

AU - Grarup, Niels

AU - Jørgensen, Torben

AU - Sparsø, Thomas

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Karpe, Fredrik

AU - Kyvik, Kirsten O

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DO - 10.1371/journal.pgen.1002607

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VL - 8

SP - e1002607

JO - P L o S Genetics

JF - P L o S Genetics

SN - 1553-7390

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