Nutrition and lifestyle-related factors as predictors of muscle atrophy in hematological cancer patients

Christiane S Staxen*, Sara E Andersen, Lars Møller Pedersen, Christian Bjørn Poulsen, Jens Rikardt Andersen

*Corresponding author for this work

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Abstract

Background: Cancer and side effects from cytostatic treatment commonly affect nutritional status manifested as a decrease in muscle mass. We aimed to investigate the impact of nutrition and lifestyle-related factors on muscle mass in patients with hematological cancer. Methods: Dietary intake, food preferences, quality of life (QoL), and physical activity level (PAL) were monitored during 1–2 cytostatic treatment series. Body composition was estimated using bioelectrical impedance analysis (BIA). Results: 61 patients were included. Weight loss and loss of muscle mass were detected in 64% and 59% of the patients, respectively. Muscle mass was significantly positively correlated to increasing PAL (p = 0.003), while negatively correlated to increasing age (p = 0.03), physical QoL (p = 0.007), functional QoL (p = 0.05), self-perceived health (p = 0.004), and self-perceived QoL (p = 0.007). Weight was significantly positively correlated to increased intake of soft drinks (p = 0.02) as well as the favoring of bitter grain and cereal products (p = 0.03), while negatively correlated to increasing age (p = 0.03) and increasing meat intake (p = 0.009) Conclusions: Several nutritional and lifestyle-related factors affected change in body composition. The clinical significance of these changes should be investigated in controlled, interventional studies.
Original languageEnglish
Article number283
JournalNutrients
Volume16
Issue number2
Number of pages12
ISSN2072-6643
DOIs
Publication statusPublished - 2024

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