Ny markør ved trombotisk trombocytopenisk purpura.

Translated title of the contribution: New marker in thrombotic thrombocytopenic purpura

Jens Peter Gøtze, Andreas Hillarp, Anders Lindblom, Peter Björk, Karin Strandberg, Lars Bo Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

2 Citations (Scopus)

Abstract

Thrombotic microangiopathy can be caused by several conditions which are difficult to diagnose from the clinical presentation alone. Deficient enzyme activity of a newly-discovered enzyme, ADAMTS-13, can lead to thrombotic thrombocytopenic purpura (TTP). Lack of ADAMTS-13 activity causes increased concentrations of high molecular weight von Willebrand factor forms and increased platelet aggregation. Measurement of ADAMTS-13 activity is useful for the diagnosis of TTP and may also be relevant as a prognostic test for recurrent TTP.
Udgivelsesdato: 2008-Aug-11
Translated title of the contributionNew marker in thrombotic thrombocytopenic purpura
Original languageDanish
JournalUgeskrift for læger
Volume170
Issue number33
Pages (from-to)2446-9
Number of pages3
ISSN0041-5782
Publication statusPublished - 2008

Bibliographical note

Keywords: ADAM Proteins; Biological Markers; Diagnosis, Differential; Humans; Purpura, Thrombotic Thrombocytopenic; von Willebrand Factor

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