Nye muligheder på vej til behandling af aldersrelateret maculadegeneration

Irfan Rafique; Inger Christine Munch

Nye muligheder på vej til behandling af aldersrelateret maculadegeneration

Irfan Rafique
, Inger Christine Munch

Department of Clinical Medicine

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Currently, age-related macular degeneration (AMD) is untreatable, except for its neovascular complications. We review the primary pathogenesis of AMD and the pipeline of experimental interventions currently under way in clinical trials. They focus on four mechanisms: suppression of inflammation, visual cycle modification, prevention of oxidative damage and neuroprotection. Regulatory approval is years away, but the development may be accelerated by re-purposing of medications designed for systemic diseases.

Original language	English
Journal	Ugeskrift for Laeger
Volume	175
Issue number	36
Pages (from-to)	2035-8
Number of pages	4
ISSN	0041-5782
Publication status	Published - 2 Sept 2013

Access to Document

http://ugeskriftet.dk/videnskab/nye-muligheder-paa-vej-til-behandling-af-aldersrelateret-maculadegeneration

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Cite this

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title = "Nye muligheder p{\aa} vej til behandling af aldersrelateret maculadegeneration",

abstract = "Currently, age-related macular degeneration (AMD) is untreatable, except for its neovascular complications. We review the primary pathogenesis of AMD and the pipeline of experimental interventions currently under way in clinical trials. They focus on four mechanisms: suppression of inflammation, visual cycle modification, prevention of oxidative damage and neuroprotection. Regulatory approval is years away, but the development may be accelerated by re-purposing of medications designed for systemic diseases.",

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language = "English",

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T1 - Nye muligheder på vej til behandling af aldersrelateret maculadegeneration

AU - Rafique, Irfan

AU - Munch, Inger Christine

PY - 2013/9/2

Y1 - 2013/9/2

N2 - Currently, age-related macular degeneration (AMD) is untreatable, except for its neovascular complications. We review the primary pathogenesis of AMD and the pipeline of experimental interventions currently under way in clinical trials. They focus on four mechanisms: suppression of inflammation, visual cycle modification, prevention of oxidative damage and neuroprotection. Regulatory approval is years away, but the development may be accelerated by re-purposing of medications designed for systemic diseases.

AB - Currently, age-related macular degeneration (AMD) is untreatable, except for its neovascular complications. We review the primary pathogenesis of AMD and the pipeline of experimental interventions currently under way in clinical trials. They focus on four mechanisms: suppression of inflammation, visual cycle modification, prevention of oxidative damage and neuroprotection. Regulatory approval is years away, but the development may be accelerated by re-purposing of medications designed for systemic diseases.

M3 - Journal article

C2 - 23992911

SN - 0041-5782

VL - 175

SP - 2035

EP - 2038

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 36

ER -