Abstract
Following Liebeskind et al [1], we have attempted to find consensus ages for the protein-coding and the noncoding genes of the human genome, using publicly-available ortholog databases. For each database separately, we determined its age estimate for the genes it listed, determining this by identifying the earliest ortholog for the gene in question. We assigned these ages to 1 of the 19 major phylostrata defined by Domazet-Loso and Tautz [2], 2 of which were further subdivided. From these various estimates, we found the modal value if 1 was present, defining this as the consensus age for the gene. For the genes where no consensus value could be found, we recorded the median value of the age estimates across the databases interrogated. We present a resource that lists the age, as so defined, of every one of the 19,660 protein-coding genes and of 5,981 of the 16,528 non-protein-coding genes of the human genome, the age being the time when the gene was accreted to the evolving human genome. We calculate the number of genes that accreted to the genome, epoch by epoch, and consider the rate at which they accreted.
Original language | English |
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Journal | Seminars in Oncology |
Volume | 46 |
Issue number | 1 |
Pages (from-to) | 3-9 |
Number of pages | 7 |
ISSN | 0093-7754 |
DOIs | |
Publication status | Published - 2019 |
Bibliographical note
Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.Keywords
- Computational Biology
- Databases, Genetic
- Evolution, Molecular
- Genome, Human/genetics
- Humans
- Open Reading Frames/genetics
- Sequence Homology