Occurrence of cancer in a cohort of 183 persons with constitutional chromosome 7 abnormalities

H Hasle, J H Olsen, J Hansen, U Friedrich, Niels Tommerup

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Abstract

Cytogenetic abnormalities in human malignancies frequently involve chromosome 7. The existence of several tumor suppressor genes on the long arm of chromosome 7 has been suggested in both epithelial and hematologic malignancies. From the Danish Cytogenetic Register, we identified 183 persons with constitutional abnormalities involving chromosome 7, including 16 patients with Williams syndrome. By linkage to the Danish Cancer Registry, we found five persons with cancer, including one thyroid carcinoma, three carcinomas of the digestive tract, and one malignant melanoma. There were no cases of leukemia. The overall risk of developing cancer was not increased.
Original languageEnglish
JournalCancer Genetics and Cytogenetics
Volume105
Issue number1
Pages (from-to)39-42
Number of pages3
ISSN0165-4608
Publication statusPublished - 1998

Bibliographical note

Keywords: Adult; Aged; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, Pair 7; Cohort Studies; Denmark; Female; Follow-Up Studies; Genes, Tumor Suppressor; Humans; Karyotyping; Male; Middle Aged; Neoplasms; Risk

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