Omega-3 fatty acid nanocarriers: Characterization and potential applications

Anan Yaghmur; Sana Ghayas; Habibullah Jan; Gokce Dicle Kalaycioglu; S. Moein Moghimi

doi:10.1016/j.cocis.2023.101728

Omega-3 fatty acid nanocarriers: Characterization and potential applications

Anan Yaghmur^*, Sana Ghayas, Habibullah Jan, Gokce Dicle Kalaycioglu, S. Moein Moghimi

^*Corresponding author for this work

Pharmaceutical Physical and Analytical Chemistry

Research output: Contribution to journal › Review › Research › peer-review

8 Citations (Scopus)

30 Downloads (Pure)

Abstract

Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and their precursors ω-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of ω-3 PUFAs, or from single ω-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.

Original language	English
Article number	101728
Journal	Current Opinion in Colloid and Interface Science
Volume	67
Number of pages	13
ISSN	1359-0294
DOIs	https://doi.org/10.1016/j.cocis.2023.101728
Publication status	Published - 2023

Bibliographical note

Funding Information:
A.Y. acknowledges support by the Danish Council for Independent Research – Technology and Production Sciences ; references DFF-7017-00065 and 1 335-00150b . A.Y. further acknowledges financial support by Novo Nordisk Foundation (Grant number NNF22OC0079752 ) and the Danish Natural Sciences Research Council for SAXS experiments (DanScatt). S. G. and H. J. postdoctoral and PhD studies, respectively, are financed by the Higher Education Commission of Pakistan (HEC) . G. D. K. is awarded 2219 postdoctoral grant (number 1059B192203132) by the Scientific and Technological Research Council of Turkey (TUBITAK).

Publisher Copyright:
© 2023 The Author(s)

Keywords

Cubosomes
Hexosomes
Inverse non-lamellar lyotropic liquid crystalline phases
Omega-3 fatty acid monoacylglycerols
Omega-3 fatty acids

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Cite this

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title = "Omega-3 fatty acid nanocarriers: Characterization and potential applications",

abstract = "Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and their precursors ω-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of ω-3 PUFAs, or from single ω-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.",

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author = "Anan Yaghmur and Sana Ghayas and Habibullah Jan and Kalaycioglu, {Gokce Dicle} and Moghimi, {S. Moein}",

note = "Funding Information: A.Y. acknowledges support by the Danish Council for Independent Research – Technology and Production Sciences ; references DFF-7017-00065 and 1 335-00150b . A.Y. further acknowledges financial support by Novo Nordisk Foundation (Grant number NNF22OC0079752 ) and the Danish Natural Sciences Research Council for SAXS experiments (DanScatt). S. G. and H. J. postdoctoral and PhD studies, respectively, are financed by the Higher Education Commission of Pakistan (HEC) . G. D. K. is awarded 2219 postdoctoral grant (number 1059B192203132) by the Scientific and Technological Research Council of Turkey (TUBITAK). Publisher Copyright: {\textcopyright} 2023 The Author(s)",

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AU - Moghimi, S. Moein

N1 - Funding Information: A.Y. acknowledges support by the Danish Council for Independent Research – Technology and Production Sciences ; references DFF-7017-00065 and 1 335-00150b . A.Y. further acknowledges financial support by Novo Nordisk Foundation (Grant number NNF22OC0079752 ) and the Danish Natural Sciences Research Council for SAXS experiments (DanScatt). S. G. and H. J. postdoctoral and PhD studies, respectively, are financed by the Higher Education Commission of Pakistan (HEC) . G. D. K. is awarded 2219 postdoctoral grant (number 1059B192203132) by the Scientific and Technological Research Council of Turkey (TUBITAK). Publisher Copyright: © 2023 The Author(s)

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N2 - Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and their precursors ω-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of ω-3 PUFAs, or from single ω-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.

AB - Lyotropic non-lamellar liquid crystalline (LLC) nano-self-assemblies (including cubosomes and hexosomes) are attractive versatile platforms for the encapsulation and delivery of drugs and nutritional molecules. This is due to their unique structural features and architectural arrangements that afford loading of small molecules and macromolecules having different physicochemical properties with high efficiency. Considering the reported health-promoting effects of long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and their precursors ω-3 PUFA monoacylglycerols; here, we focus on physicochemical and biological properties of a new family of non-lamellar LLC nanoparticles assembled either from binary mixtures of phosphatidylglycerol and three types of ω-3 PUFAs, or from single ω-3 PUFA monoacylglycerols. We discuss recent progress in understanding their complexity, pH sensitivity, and structural tunability, as well as highlight their potential applications in health and medicine.

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DO - 10.1016/j.cocis.2023.101728

M3 - Review

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JO - Current Opinion in Colloid & Interface Science

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