TY - UNPB
T1 - Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface
AU - Meneghetti, Marcello
AU - Kaur, Jaspreet
AU - Sui, Kunyang
AU - Sørensen, Roar Jakob Fleng
AU - Berg, Rune W.
AU - Markos, Christos
PY - 2022/5/23
Y1 - 2022/5/23
N2 - Controlling neuronal activity with high spatial resolution using multifunctional and minimally invasive neural interfaces constitutes an important step towards developments in neuroscience and novel treatments for brain diseases. While infrared neuromodulation is an emerging technology for controlling the neuronal circuitry, it lacks soft implantable monolithic interfaces capable of simultaneously delivering light and recording electrical signals from the brain while being mechanically brain-compatible. Here, we have developed a soft fibre-based device based on high-performance thermoplastics which are >100-fold softer than silica glass. The presented fibre-implant is capable of safely neuromodulating the brain activity in localized cortical domains by delivering infrared laser pulses in the 2 μm spectral region while recording electrophysiological signals. Action and local field potentials were recorded in vivo in adult rats while immunohistochemical analysis of the tissue indicated limited microglia and monocytes response introduced by the fibre and the infrared pulses. We expect our devices to further enhance infrared neuromodulation as a versatile approach for fundamental research and clinically translatable therapeutic interventions.
AB - Controlling neuronal activity with high spatial resolution using multifunctional and minimally invasive neural interfaces constitutes an important step towards developments in neuroscience and novel treatments for brain diseases. While infrared neuromodulation is an emerging technology for controlling the neuronal circuitry, it lacks soft implantable monolithic interfaces capable of simultaneously delivering light and recording electrical signals from the brain while being mechanically brain-compatible. Here, we have developed a soft fibre-based device based on high-performance thermoplastics which are >100-fold softer than silica glass. The presented fibre-implant is capable of safely neuromodulating the brain activity in localized cortical domains by delivering infrared laser pulses in the 2 μm spectral region while recording electrophysiological signals. Action and local field potentials were recorded in vivo in adult rats while immunohistochemical analysis of the tissue indicated limited microglia and monocytes response introduced by the fibre and the infrared pulses. We expect our devices to further enhance infrared neuromodulation as a versatile approach for fundamental research and clinically translatable therapeutic interventions.
KW - Faculty of Health and Medical Sciences
UR - https://www.biorxiv.org/content/10.1101/2022.05.23.493057v1
U2 - 10.1101/2022.05.23.493057
DO - 10.1101/2022.05.23.493057
M3 - Preprint
T3 - bioRxiv
SP - 1
EP - 19
BT - Opsin-free optical neuromodulation and electrophysiology enabled by a soft monolithic infrared multifunctional neural interface
ER -