Optic disc drusen: Dystrophic calcification, a potential target for treatment

Josephine Mejdahl Bentin, Steffen Heegaard, Niklas Rye Jørgensen, Louise Grahnemo, Steffen Hamann*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

1 Citation (Scopus)

Abstract

Optic disc drusen (ODD) are calcified, acellular bodies, seen in the optic nerve head of up to 2% of the population. Although seldomly affecting visual acuity, visual field defects are common, and severe, ischemic complications causing irreversible vision loss are known to occur. Different treatment strategies for ODD have been explored, but so far without success. This review focuses on the unique, calcified property of ODD, describing what we know about ODD pathogenesis and previously tried treatment strategies. In this context, we discuss current knowledge about calcium and pathological calcifications, including intracranial and ocular calcifications. We also explore some of the obstacles that must be addressed to develop a therapy centred on the concept of calcification, should calcification be identified as a pathogenic factor contributing to vision loss.

Original languageEnglish
JournalEye
Volume38
Issue number12
Pages (from-to)2359-2364
Number of pages6
ISSN0950-222X
DOIs
Publication statusPublished - 2024

Bibliographical note

Publisher Copyright:
© The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2024.

Cite this