Optogenetic control of human neurons in organotypic brain cultures

My Andersson; Natalia Avaliani; Andreas Svensson; Jenny Wickham; Lars H Pinborg; Bo Jespersen; Søren H Christiansen; Johan Bengzon; David P D Woldbye; Merab Kokaia

doi:10.1038/srep24818

Optogenetic control of human neurons in organotypic brain cultures

My Andersson, Natalia Avaliani, Andreas Svensson, Jenny Wickham, Lars H Pinborg, Bo Jespersen, Søren H Christiansen, Johan Bengzon, David P D Woldbye, Merab Kokaia

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Abstract

Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.

Original language	English
Article number	24818
Journal	Scientific Reports
Volume	6
Number of pages	5
ISSN	2045-2322
DOIs	https://doi.org/10.1038/srep24818
Publication status	Published - 21 Apr 2016

Keywords

Journal Article
Research Support, Non-U.S. Gov't

Access to Document

10.1038/srep24818Licence: CC BY

Optogenetic control of human neurons in organotypic brain culturesFinal published version, 1.21 MBLicence: CC BY

Cite this

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AU - Andersson, My

AU - Avaliani, Natalia

AU - Svensson, Andreas

AU - Wickham, Jenny

AU - Pinborg, Lars H

AU - Jespersen, Bo

AU - Christiansen, Søren H

AU - Bengzon, Johan

AU - Woldbye, David P D

AU - Kokaia, Merab

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AB - Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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