Orally active-targeted drug delivery systems for proteins and peptides

Xiuying Li, Miaorong Yu, Weiwei Fan, Yong Gan*, Lars Hovgaard, Mingshi Yang

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

32 Citations (Scopus)

Abstract

Introduction: In the past decade, extensive efforts have been devoted to designing 'active targeted' drug delivery systems (ATDDS) to improve oral absorption of proteins and peptides. Such ATDDS enhance cellular internalization and permeability of proteins and peptides via molecular recognition processes such as ligand-receptor or antigen-antibody interaction, and thus enhance drug absorption.Areas covered: This review focuses on recent advances with orally ATDDS, including ligand-protein conjugates, recombinant ligand-protein fusion proteins and ligand-modified carriers. In addition to traditional intestinal active transport systems of substrates and their corresponding receptors, transporters and carriers, new targets such as intercellular adhesion molecule-1 and β-integrin are also discussed.Expert opinion: ATDDS can improve oral absorption of proteins and peptides. However, currently, no clinical studies on ATDDS for proteins and peptides are underway, perhaps due to the complexity and limited knowledge of transport mechanisms. Therefore, more research is warranted to optimize ATDDS efficiency.

Original languageEnglish
JournalExpert Opinion on Drug Delivery
Volume11
Issue number9
Pages (from-to)1435-1447
Number of pages13
ISSN1742-5247
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Active-targeted drug delivery systems
  • IgG-Fc receptor
  • Intercellular adhesion molecule-1
  • Oral protein and peptide delivery
  • Proton-coupled folate transporter
  • Recombinant fusion protein
  • Transferrin receptor

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