Osteopontin deficiency dampens the pro-atherogenic effect of uraemia

Tanja Xenia Pedersen, Marie Madsen, Nanna Maria Junker Nielsen, Christina Christoffersen, Jonas Vikeså, Susanne Bro, Anna Hultgårdh-Nilsson, Lars Bo Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

17 Citations (Scopus)

Abstract

Uraemia is a strong risk factor for cardiovascular disease. Osteopontin (OPN) is highly expressed in aortas of uraemic apolipoprotein E knockout (E KO) mice. OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice.
Original languageEnglish
JournalCardiovascular Research
Volume98
Issue number3
Pages (from-to)352-9
Number of pages8
ISSN0008-6363
DOIs
Publication statusPublished - 1 Jun 2013

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