Abstract
Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.
Original language | English |
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Journal | Cell Research |
Volume | 26 |
Issue number | 11 |
Pages (from-to) | 1176-1177 |
Number of pages | 2 |
ISSN | 1001-0602 |
DOIs | |
Publication status | Published - Nov 2016 |
Keywords
- Endopeptidases
- Immunity, Innate
- Lymphocytes
- Neurotransmitter Agents
- Ubiquitin