OTULIN deficiency causes auto-inflammatory syndrome

Berthe Katrine Fiil; Mads Gyrd-Hansen

doi:10.1038/cr.2016.113

OTULIN deficiency causes auto-inflammatory syndrome

Berthe Katrine Fiil, Mads Gyrd-Hansen

Skin Immunology Research Center

Research output: Contribution to journal › Journal article › Commissioned

12 Citations (Scopus)

Abstract

Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.

Original language	English
Journal	Cell Research
Volume	26
Issue number	11
Pages (from-to)	1176-1177
Number of pages	2
ISSN	1001-0602
DOIs	https://doi.org/10.1038/cr.2016.113
Publication status	Published - Nov 2016

Keywords

Endopeptidases
Immunity, Innate
Lymphocytes
Neurotransmitter Agents
Ubiquitin

Access to Document

10.1038/cr.2016.113

Cite this

@article{6146b1bcde094732895c59824cf9ed6b,

title = "OTULIN deficiency causes auto-inflammatory syndrome",

abstract = "Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.",

keywords = "Endopeptidases, Immunity, Innate, Lymphocytes, Neurotransmitter Agents, Ubiquitin",

author = "Fiil, {Berthe Katrine} and Mads Gyrd-Hansen",

year = "2016",

month = nov,

doi = "10.1038/cr.2016.113",

language = "English",

volume = "26",

pages = "1176--1177",

journal = "Cell Research",

issn = "1001-0602",

publisher = "nature publishing group",

number = "11",

}

TY - JOUR

T1 - OTULIN deficiency causes auto-inflammatory syndrome

AU - Fiil, Berthe Katrine

AU - Gyrd-Hansen, Mads

PY - 2016/11

Y1 - 2016/11

N2 - Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.

AB - Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.

KW - Endopeptidases

KW - Immunity, Innate

KW - Lymphocytes

KW - Neurotransmitter Agents

KW - Ubiquitin

U2 - 10.1038/cr.2016.113

DO - 10.1038/cr.2016.113

M3 - Journal article

C2 - 27686184

VL - 26

SP - 1176

EP - 1177

JO - Cell Research

JF - Cell Research

SN - 1001-0602

IS - 11

ER -