OTULIN deficiency causes auto-inflammatory syndrome

Research output: Contribution to journalJournal articleCommissioned

12 Citations (Scopus)

Abstract

Ubiquitin chains assembled via the N-terminal methionine (Met1 or linear ubiquitin), conjugated by the linear ubiquitin chain assembly complex (LUBAC), participate in NF-κΒ-dependent inflammatory signaling and immune responses. A recent report in Cell finds that OTULIN, a deubiquitinase that selectively cleaves Met1-linked ubiquitin chains, is essential for restraining inflammation in vivo.

Original languageEnglish
JournalCell Research
Volume26
Issue number11
Pages (from-to)1176-1177
Number of pages2
ISSN1001-0602
DOIs
Publication statusPublished - Nov 2016

Keywords

  • Endopeptidases
  • Immunity, Innate
  • Lymphocytes
  • Neurotransmitter Agents
  • Ubiquitin

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