Outcome of peripheral T-cell lymphoma in first complete remission: a Danish-Swedish population-based study

Henrik Cederleuf*, Lasse Hjort Jakobsen, Fredrik Ellin, Peter de Nully Brown, Thomas Stauffer Larsen, Martin Bøgsted, Thomas Relander, Mats Jerkeman, Tarec Christoffer El-Galaly

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

21 Citations (Scopus)

Abstract

In the present study, we investigate the outcome of 109 Danish and 123 Swedish patients with nodal PTCL in first complete remission (CR), and examine the impact of imaging-based follow-up (FU) strategies. The patients were selected by the following criteria: (a) newly diagnosed nodal PTCL from 2007 to 2012, (b) age ≥18 years, and (c) CR after CHOP or CHOEP therapy. FU guidelines in Sweden included symptom assessment, clinical examinations and blood tests at 3–4-month intervals for 2 years. FU strategies in Denmark was similar but included routine imaging, usually every 6 months for 2 years. Patients had fully comparable characteristics. Overall survival (OS) estimates for patients in CR were similar for all patients (p =.6) and in PTCL subtypes. In multivariate analysis, country of follow-up had no impact on OS. However, despite continuous CR for ≥2 years, the OS of PTCL remained inferior to a matched general population.

Original languageEnglish
JournalLeukemia and Lymphoma
Volume58
Issue number12
Pages (from-to)2815-2823
Number of pages9
ISSN1042-8194
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Peripheral T-cell lymphoma
  • population based
  • routine imaging

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