TY - JOUR
T1 - Palladium-catalyzed asymmetric allylic alkylation of a-aryl ketones
AU - Trost, B.M.
AU - Schroeder, G.M.
AU - Kristensen, Jesper Langgaard
PY - 2002/9/16
Y1 - 2002/9/16
N2 - Quaternary centers can be created asymmetrically in high enantiomeric excess by the proper choice of ligand and metal cation in the Pd-catalyzed asymmetric allylic alkylation of a-aryl ketones. A broad range of ketone enolates can be tolerated in the reaction, as illustrated by the synthesis of conformationally constrained ß-tetralone in 96% ee (see scheme, DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).
AB - Quaternary centers can be created asymmetrically in high enantiomeric excess by the proper choice of ligand and metal cation in the Pd-catalyzed asymmetric allylic alkylation of a-aryl ketones. A broad range of ketone enolates can be tolerated in the reaction, as illustrated by the synthesis of conformationally constrained ß-tetralone in 96% ee (see scheme, DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).
UR - http://www.scopus.com/inward/record.url?scp=0037119732&partnerID=8YFLogxK
U2 - 10.1002/1521-3773(20020916)41:18<3492::AID-ANIE3492>3.0.CO;2-P
DO - 10.1002/1521-3773(20020916)41:18<3492::AID-ANIE3492>3.0.CO;2-P
M3 - Journal article
AN - SCOPUS:0037119732
VL - 41
SP - 3492
EP - 3495
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
SN - 1433-7851
IS - 18
ER -