Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

Maria Siopi; Antonios Papadopoulos; Anastasia Spiliopoulou; Fotini Paliogianni; Nissrine Abou-chakra; Maiken Cavling Arendrup; Christina Damoulari; Georgios Tsioulos; Efthymia Giannitsioti; Frantzeska Frantzeskaki; Iraklis Tsangaris; Spyros Pournaras; Joseph Meletiadis

doi:10.3390/jof8090931

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy

Maria Siopi, Antonios Papadopoulos, Anastasia Spiliopoulou, Fotini Paliogianni, Nissrine Abou-chakra, Maiken Cavling Arendrup, Christina Damoulari, Georgios Tsioulos, Efthymia Giannitsioti, Frantzeska Frantzeskaki, Iraklis Tsangaris, Spyros Pournaras, Joseph Meletiadis

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.

Original language	English
Article number	931
Journal	Journal of Fungi
Volume	8
Issue number	9
Number of pages	7
DOIs	https://doi.org/10.3390/jof8090931
Publication status	Published - 2022

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Siopi, M., Papadopoulos, A., Spiliopoulou, A., Paliogianni, F., Abou-chakra, N., Arendrup, M. C., Damoulari, C., Tsioulos, G., Giannitsioti, E., Frantzeskaki, F., Tsangaris, I., Pournaras, S., & Meletiadis, J. (2022). Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy. Journal of Fungi, 8(9), [931]. https://doi.org/10.3390/jof8090931

Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy. / Siopi, Maria; Papadopoulos, Antonios; Spiliopoulou, Anastasia; Paliogianni, Fotini; Abou-chakra, Nissrine; Arendrup, Maiken Cavling; Damoulari, Christina; Tsioulos, Georgios; Giannitsioti, Efthymia; Frantzeskaki, Frantzeska; Tsangaris, Iraklis; Pournaras, Spyros; Meletiadis, Joseph.

In: Journal of Fungi, Vol. 8, No. 9, 931, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Siopi, M, Papadopoulos, A, Spiliopoulou, A, Paliogianni, F, Abou-chakra, N, Arendrup, MC, Damoulari, C, Tsioulos, G, Giannitsioti, E, Frantzeskaki, F, Tsangaris, I, Pournaras, S & Meletiadis, J 2022, 'Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy', Journal of Fungi, vol. 8, no. 9, 931. https://doi.org/10.3390/jof8090931

Siopi, Maria ; Papadopoulos, Antonios ; Spiliopoulou, Anastasia ; Paliogianni, Fotini ; Abou-chakra, Nissrine ; Arendrup, Maiken Cavling ; Damoulari, Christina ; Tsioulos, Georgios ; Giannitsioti, Efthymia ; Frantzeskaki, Frantzeska ; Tsangaris, Iraklis ; Pournaras, Spyros ; Meletiadis, Joseph. / Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy. In: Journal of Fungi. 2022 ; Vol. 8, No. 9.

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title = "Pan-Echinocandin Resistant C. parapsilosis Harboring an F652S Fks1 Alteration in a Patient with Prolonged Echinocandin Therapy",

abstract = "The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.",

author = "Maria Siopi and Antonios Papadopoulos and Anastasia Spiliopoulou and Fotini Paliogianni and Nissrine Abou-chakra and Arendrup, {Maiken Cavling} and Christina Damoulari and Georgios Tsioulos and Efthymia Giannitsioti and Frantzeska Frantzeskaki and Iraklis Tsangaris and Spyros Pournaras and Joseph Meletiadis",

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AU - Siopi, Maria

AU - Papadopoulos, Antonios

AU - Spiliopoulou, Anastasia

AU - Paliogianni, Fotini

AU - Abou-chakra, Nissrine

AU - Arendrup, Maiken Cavling

AU - Damoulari, Christina

AU - Tsioulos, Georgios

AU - Giannitsioti, Efthymia

AU - Frantzeskaki, Frantzeska

AU - Tsangaris, Iraklis

AU - Pournaras, Spyros

AU - Meletiadis, Joseph

PY - 2022

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N2 - The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.

AB - The isolation of a pan-echinocandin-resistant Candida parapsilosis strain (anidulafungin, caspofungin, micafungin and rezafungin EUCAST MICs > 8 mg/L) from urine of a patient following prolonged exposure to echinocandins (38 days of micafungin followed by 16 days of anidulafungin) is described. The isolate harbored the novel alteration F652S in the hotspot 1 region of fks1. Isogenic C. parapsilosis bloodstream isolates collected up to 1.5 months earlier from the same patient were susceptible to echinocandins (anidulafungin, caspofungin and micafungin EUCAST MICs 1–2, 1 and 1 mg/L, respectively) and contained wild-type FKS1 sequences. This is the first report of pan-echinocandin resistance in C. parapsilosis associated with an aminoacid change in hotspot 1 region of fks1.

U2 - 10.3390/jof8090931

DO - 10.3390/jof8090931

M3 - Journal article

C2 - 36135656

VL - 8

JO - Journal of Fungi

JF - Journal of Fungi

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