Parkinson's disease and mitochondrial gene variations: A review

Sasan Andalib, Manouchehr Seyedi Vafaee, Albert Gjedde

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26 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.

Original languageEnglish
JournalJournal of the Neurological Sciences
Volume346
Issue number1-2
Pages (from-to)11-19
Number of pages9
ISSN0022-510X
DOIs
Publication statusPublished - 7 Aug 2014

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