Pathophysiological-based treatments of complications of cirrhosis

Søren Møller*, Nina Kimer, Mads Barlose, Flemming Bendtsen

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

6 Citations (Scopus)

Abstract

Detailed knowledge and understanding of the pathophysiological mechanisms and changes in hepatic and splanchnic function leading to the development of haemodynamic changes and portal hypertension in patients with cirrhosis are essential since it guides the search for targets to ameliorate liver-related abnormalities. Recent research has focused on the gut-liver axis, changes in intestinal permeability, translocation of bacterial products, and inflammation as important drivers of haemodynamic alterations and thereby targets for treatment. Additionally, treatment strategies should focus on microbiotic modulation, antiangiogenics, anti-inflammatory strategies, and modulation of bile acid metabolism. This paper aims to review contemporary pathophysiological-based treatment principles of the major complications of cirrhosis and portal hypertension and future targets for treatment.

Original languageEnglish
Book seriesScandinavian Journal of Gastroenterology
Volume55
Issue number4
Pages (from-to)383-394
ISSN0036-5521
DOIs
Publication statusPublished - 2020

Keywords

  • Portal hypertension
  • ascites
  • oesophageal varices
  • hyperdynamic circulation
  • hepatorenal syndrome
  • hepatopulmonary syndrome
  • NITRIC-OXIDE SYNTHASE
  • PORTAL-HYPERTENSION RELATION
  • HEPATIC STELLATE CELLS
  • ARGININE METHYL-ESTER
  • CHRONIC LIVER-FAILURE
  • NECROSIS-FACTOR-ALPHA
  • PORTOPULMONARY HYPERTENSION
  • HEPATOPULMONARY SYNDROME
  • BETA-BLOCKERS
  • HYPERDYNAMIC CIRCULATION

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