Abstract
Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
| Original language | English |
|---|---|
| Journal | Allergy: European Journal of Allergy and Clinical Immunology |
| Volume | 78 |
| Issue number | 7 |
| Pages (from-to) | 1758-1776 |
| Number of pages | 19 |
| ISSN | 0105-4538 |
| DOIs | |
| Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
Keywords
- apps
- ARIA
- digital health
- EAACI
- rhinitis
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Patient-centered digital biomarkers for allergic respiratory diseases and asthma : The ARIA-EAACI approach – ARIA-EAACI Task Force Report. / Bousquet, Jean; Shamji, Mohamed H.; Anto, Josep M.; Schünemann, Holger J.; Canonica, G. Walter; Jutel, Marek; Del Giacco, Stefano; Zuberbier, Torsten; Pfaar, Oliver; Fonseca, Joao A.; Sousa-Pinto, Bernardo; Klimek, Ludger; Czarlewski, Wienczyslawa; Bedbrook, Anna; Amaral, Rita; Ansotegui, Ignacio J.; Bosnic-Anticevich, Sinthia; Braido, Fulvio; Chaves Loureiro, Claudia; Gemicioglu, Bilun; Haahtela, Tari; Kulus, Marek; Kuna, Piotr; Kupczyk, Maciej; Matricardi, Paolo M; Regateiro, Frederico S.; Samolinski, Boleslaw; Sofiev, Mikhail; Toppila-Salmi, Sanna; Valiulis, Arunas; Ventura, Maria Teresa; Barbara, Cristina; Bergmann, Karl C.; Bewick, Michael; Blain, Hubert; Bonini, Matteo; Boulet, Louis Philippe; Bourret, Rodolphe; Brusselle, Guy; Brussino, Luisa; Buhl, Roland; Cardona, Victoria; Casale, Thomas; Cecchi, Lorenzo; Charpin, Denis; Cherrez-Ojeda, Ivan; Chu, Derek K.; Cingi, Cemal; Costa, Elisio M.; Cruz, Alvaro A; Devillier, Philippe; Dramburg, Stephanie; Fokkens, Wytske J; Gotua, Maia; Heffler, Enrico; Ispayeva, Zhanat; Ivancevich, Juan Carlos; Joos, Guy; Kaidashev, Igor; Kraxner, Helga; Kvedariene, Violeta; Larenas-Linnemann, Désirée E.; Laune, Daniel; Lourenço, Olga; Louis, Renaud; Makela, Mika; Makris, Michael; Maurer, Marcus; Melén, Erik; Micheli, Yann; Morais-Almeida, Mario; Mullol, Joaquim; Niedoszytko, Marek; O'Hehir, Robyn; Okamoto, Yoshitaka; Olze, Heidi; Papadopoulos, Nikolaos G.; Papi, Alberto; Patella, Vincenzo; Pétré, Benoit; Pham-Thi, Nhân; Puggioni, Francesca; Quirce, Santiago; Roche, Nicolas; Rouadi, Philip W; Sá-Sousa, Ana; Sagara, Hironori; Sastre, Joaquin; Scichilone, Nicola; Sheikh, Aziz; Sova, Milan; Suppli Ulrik, Charlotte; Taborda-Barata, Luis; Todo-Bom, Ana; Torres, Maria J; Tsiligianni, Ioanna; Usmani, Omar S.; Valovirta, Erkka; Vasankari, Tuula; Vieira, Rafael José; Wallace, Dana; Waserman, Susan; Zidarn, Mihaela; Yorgancioglu, Arzu; Zhang, Luo; Chivato, Tomas; Ollert, Markus.
In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 78, No. 7, 2023, p. 1758-1776.Research output: Contribution to journal › Journal article › Research › peer-review
}
TY - JOUR
T1 - Patient-centered digital biomarkers for allergic respiratory diseases and asthma
T2 - The ARIA-EAACI approach – ARIA-EAACI Task Force Report
AU - Bousquet, Jean
AU - Shamji, Mohamed H.
AU - Anto, Josep M.
AU - Schünemann, Holger J.
AU - Canonica, G. Walter
AU - Jutel, Marek
AU - Del Giacco, Stefano
AU - Zuberbier, Torsten
AU - Pfaar, Oliver
AU - Fonseca, Joao A.
AU - Sousa-Pinto, Bernardo
AU - Klimek, Ludger
AU - Czarlewski, Wienczyslawa
AU - Bedbrook, Anna
AU - Amaral, Rita
AU - Ansotegui, Ignacio J.
AU - Bosnic-Anticevich, Sinthia
AU - Braido, Fulvio
AU - Chaves Loureiro, Claudia
AU - Gemicioglu, Bilun
AU - Haahtela, Tari
AU - Kulus, Marek
AU - Kuna, Piotr
AU - Kupczyk, Maciej
AU - Matricardi, Paolo M
AU - Regateiro, Frederico S.
AU - Samolinski, Boleslaw
AU - Sofiev, Mikhail
AU - Toppila-Salmi, Sanna
AU - Valiulis, Arunas
AU - Ventura, Maria Teresa
AU - Barbara, Cristina
AU - Bergmann, Karl C.
AU - Bewick, Michael
AU - Blain, Hubert
AU - Bonini, Matteo
AU - Boulet, Louis Philippe
AU - Bourret, Rodolphe
AU - Brusselle, Guy
AU - Brussino, Luisa
AU - Buhl, Roland
AU - Cardona, Victoria
AU - Casale, Thomas
AU - Cecchi, Lorenzo
AU - Charpin, Denis
AU - Cherrez-Ojeda, Ivan
AU - Chu, Derek K.
AU - Cingi, Cemal
AU - Costa, Elisio M.
AU - Cruz, Alvaro A
AU - Devillier, Philippe
AU - Dramburg, Stephanie
AU - Fokkens, Wytske J
AU - Gotua, Maia
AU - Heffler, Enrico
AU - Ispayeva, Zhanat
AU - Ivancevich, Juan Carlos
AU - Joos, Guy
AU - Kaidashev, Igor
AU - Kraxner, Helga
AU - Kvedariene, Violeta
AU - Larenas-Linnemann, Désirée E.
AU - Laune, Daniel
AU - Lourenço, Olga
AU - Louis, Renaud
AU - Makela, Mika
AU - Makris, Michael
AU - Maurer, Marcus
AU - Melén, Erik
AU - Micheli, Yann
AU - Morais-Almeida, Mario
AU - Mullol, Joaquim
AU - Niedoszytko, Marek
AU - O'Hehir, Robyn
AU - Okamoto, Yoshitaka
AU - Olze, Heidi
AU - Papadopoulos, Nikolaos G.
AU - Papi, Alberto
AU - Patella, Vincenzo
AU - Pétré, Benoit
AU - Pham-Thi, Nhân
AU - Puggioni, Francesca
AU - Quirce, Santiago
AU - Roche, Nicolas
AU - Rouadi, Philip W
AU - Sá-Sousa, Ana
AU - Sagara, Hironori
AU - Sastre, Joaquin
AU - Scichilone, Nicola
AU - Sheikh, Aziz
AU - Sova, Milan
AU - Suppli Ulrik, Charlotte
AU - Taborda-Barata, Luis
AU - Todo-Bom, Ana
AU - Torres, Maria J
AU - Tsiligianni, Ioanna
AU - Usmani, Omar S.
AU - Valovirta, Erkka
AU - Vasankari, Tuula
AU - Vieira, Rafael José
AU - Wallace, Dana
AU - Waserman, Susan
AU - Zidarn, Mihaela
AU - Yorgancioglu, Arzu
AU - Zhang, Luo
AU - Chivato, Tomas
AU - Ollert, Markus
N1 - Publisher Copyright: © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
AB - Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
KW - apps
KW - ARIA
KW - digital health
KW - EAACI
KW - rhinitis
U2 - 10.1111/all.15740
DO - 10.1111/all.15740
M3 - Journal article
C2 - 37042071
AN - SCOPUS:85164233199
VL - 78
SP - 1758
EP - 1776
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 7
ER -