Percutaneous penetration characteristics and release kinetics of contact allergens encapsulated in ethosomes

Jakob Torp Madsen; Stefan Vogel; Jeanne Duus Johansen; Jens Ahm Sørensen; Klaus Ejner Andersen; Jesper Bo Nielsen

doi:10.3109/15569527.2010.521220

Percutaneous penetration characteristics and release kinetics of contact allergens encapsulated in ethosomes

Jakob Torp Madsen, Stefan Vogel, Jeanne Duus Johansen, Jens Ahm Sørensen, Klaus Ejner Andersen, Jesper Bo Nielsen

Research output: Contribution to journal › Journal article › Research › peer-review

10 Citations (Scopus)

Abstract

Formulation of the contact allergens dinitrochlorobenzene and isoeugenol in ethanolic liposomes (ethosomes) increases their sensitizing properties in the local lymph node assay compared with an ethanol-water formulation of the allergens. Likewise, isoeugenol and methyldibromo-glutaronitrile formulated in ethosomes enhanced the patch test reactions in sensitized human volunteers. The relationship between the percutaneous penetration/absorption and sensitization/elicitation phases of contact allergy is not well elucidated.

Original language	English
Journal	Cutaneous and Ocular Toxicology
Volume	30
Issue number	1
Pages (from-to)	38-44
Number of pages	7
ISSN	1556-9527
DOIs	https://doi.org/10.3109/15569527.2010.521220
Publication status	Published - 1 Mar 2011

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10.3109/15569527.2010.521220

Cite this

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title = "Percutaneous penetration characteristics and release kinetics of contact allergens encapsulated in ethosomes",

abstract = "Formulation of the contact allergens dinitrochlorobenzene and isoeugenol in ethanolic liposomes (ethosomes) increases their sensitizing properties in the local lymph node assay compared with an ethanol-water formulation of the allergens. Likewise, isoeugenol and methyldibromo-glutaronitrile formulated in ethosomes enhanced the patch test reactions in sensitized human volunteers. The relationship between the percutaneous penetration/absorption and sensitization/elicitation phases of contact allergy is not well elucidated.",

author = "Madsen, {Jakob Torp} and Stefan Vogel and Johansen, {Jeanne Duus} and S{\o}rensen, {Jens Ahm} and Andersen, {Klaus Ejner} and Nielsen, {Jesper Bo}",

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AU - Madsen, Jakob Torp

AU - Vogel, Stefan

AU - Johansen, Jeanne Duus

AU - Sørensen, Jens Ahm

AU - Andersen, Klaus Ejner

AU - Nielsen, Jesper Bo

PY - 2011/3/1

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N2 - Formulation of the contact allergens dinitrochlorobenzene and isoeugenol in ethanolic liposomes (ethosomes) increases their sensitizing properties in the local lymph node assay compared with an ethanol-water formulation of the allergens. Likewise, isoeugenol and methyldibromo-glutaronitrile formulated in ethosomes enhanced the patch test reactions in sensitized human volunteers. The relationship between the percutaneous penetration/absorption and sensitization/elicitation phases of contact allergy is not well elucidated.

AB - Formulation of the contact allergens dinitrochlorobenzene and isoeugenol in ethanolic liposomes (ethosomes) increases their sensitizing properties in the local lymph node assay compared with an ethanol-water formulation of the allergens. Likewise, isoeugenol and methyldibromo-glutaronitrile formulated in ethosomes enhanced the patch test reactions in sensitized human volunteers. The relationship between the percutaneous penetration/absorption and sensitization/elicitation phases of contact allergy is not well elucidated.

U2 - 10.3109/15569527.2010.521220

DO - 10.3109/15569527.2010.521220

M3 - Journal article

SN - 1556-9527

VL - 30

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JF - Cutaneous and Ocular Toxicology

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