TY - JOUR
T1 - Perfusion imaging using rubidium-82 ((82)Rb) PET in rats with myocardial infarction
T2 - First small animal cardiac (82)Rb-PET
AU - Clemmensen, Andreas Ettrup
AU - Ghotbi, Adam Ali
AU - Bodholdt, Rasmus Poul
AU - Hag, Anne Mette Fisker
AU - Hasbak, Philip
AU - Ripa, Rasmus Sejersten
AU - Kjaer, Andreas
PY - 2017/2
Y1 - 2017/2
N2 - Assessing myocardial perfusion using 82Rb-PET is emerging as a valuable clinical tool.1,2 The rapid decay (T½ = 76 s) allows for absolute quantification of both rest and stress perfusion within 30 minutes. In addition to evaluation of epicardial disease with perfusion defects, also evaluation of balanced coronary and small vessel disease is possible. For further evaluation of how 82Rb-PET can be used clinically, pre-clinical application of the method would be valuable. However, so far no data on the use of 82Rb-PET in small animals have been published nor has the use of 82Rb-PET, to the best of our knowledge, been successfully tried. Therefore, we wanted to develop and test the applicability of the method in rats, despite the high positron range of 82Rb. To do so, we adapted the clinical method and tested it in rats with experimentally induced myocardial infarction.
AB - Assessing myocardial perfusion using 82Rb-PET is emerging as a valuable clinical tool.1,2 The rapid decay (T½ = 76 s) allows for absolute quantification of both rest and stress perfusion within 30 minutes. In addition to evaluation of epicardial disease with perfusion defects, also evaluation of balanced coronary and small vessel disease is possible. For further evaluation of how 82Rb-PET can be used clinically, pre-clinical application of the method would be valuable. However, so far no data on the use of 82Rb-PET in small animals have been published nor has the use of 82Rb-PET, to the best of our knowledge, been successfully tried. Therefore, we wanted to develop and test the applicability of the method in rats, despite the high positron range of 82Rb. To do so, we adapted the clinical method and tested it in rats with experimentally induced myocardial infarction.
U2 - 10.1007/s12350-016-0564-6
DO - 10.1007/s12350-016-0564-6
M3 - Letter
C2 - 27301962
VL - 24
SP - 750
EP - 752
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
SN - 1071-3581
IS - 2
ER -