Abstract
Social isolation (SI) of rats directly after weaning is a non-pharmacological, non-lesion animal model based on the neurodevelopmental hypothesis of schizophrenia. The model causes several neurobiological and behavioral alterations consistent with observations in schizophrenia.
Original language | English |
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Journal | Psychopharmacology |
Volume | 215 |
Issue number | 2 |
Pages (from-to) | 257-66 |
Number of pages | 10 |
ISSN | 0033-3158 |
DOIs | |
Publication status | Published - 2011 |
Keywords
- Acoustic Stimulation
- Analysis of Variance
- Animals
- Animals, Newborn
- Antipsychotic Agents
- Behavior, Animal
- Cohort Studies
- Dose-Response Relationship, Drug
- Hyperkinesis
- Inhibition (Psychology)
- Male
- Motor Activity
- Psychoacoustics
- Random Allocation
- Rats
- Social Isolation
- Time Factors