Pharmacological characterization of social isolation-induced hyperactivity

Katrine Fabricius; Lone Helboe; Anders Fink-Jensen; Gitta Wörtwein; Björn Steiniger-Brach

doi:10.1007/s00213-010-2128-9

Pharmacological characterization of social isolation-induced hyperactivity

Katrine Fabricius, Lone Helboe, Anders Fink-Jensen, Gitta Wörtwein, Björn Steiniger-Brach

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Abstract

Social isolation (SI) of rats directly after weaning is a non-pharmacological, non-lesion animal model based on the neurodevelopmental hypothesis of schizophrenia. The model causes several neurobiological and behavioral alterations consistent with observations in schizophrenia.

Original language	English
Journal	Psychopharmacology
Volume	215
Issue number	2
Pages (from-to)	257-66
Number of pages	10
ISSN	0033-3158
DOIs	https://doi.org/10.1007/s00213-010-2128-9
Publication status	Published - 2011

Keywords

Acoustic Stimulation
Analysis of Variance
Animals
Animals, Newborn
Antipsychotic Agents
Behavior, Animal
Cohort Studies
Dose-Response Relationship, Drug
Hyperkinesis
Inhibition (Psychology)
Male
Motor Activity
Psychoacoustics
Random Allocation
Rats
Social Isolation
Time Factors

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Cite this

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title = "Pharmacological characterization of social isolation-induced hyperactivity",

abstract = "Social isolation (SI) of rats directly after weaning is a non-pharmacological, non-lesion animal model based on the neurodevelopmental hypothesis of schizophrenia. The model causes several neurobiological and behavioral alterations consistent with observations in schizophrenia.",

keywords = "Acoustic Stimulation, Analysis of Variance, Animals, Animals, Newborn, Antipsychotic Agents, Behavior, Animal, Cohort Studies, Dose-Response Relationship, Drug, Hyperkinesis, Inhibition (Psychology), Male, Motor Activity, Psychoacoustics, Random Allocation, Rats, Social Isolation, Time Factors",

author = "Katrine Fabricius and Lone Helboe and Anders Fink-Jensen and Gitta W{\"o}rtwein and Bj{\"o}rn Steiniger-Brach",

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language = "English",

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AU - Fabricius, Katrine

AU - Helboe, Lone

AU - Fink-Jensen, Anders

AU - Wörtwein, Gitta

AU - Steiniger-Brach, Björn

PY - 2011

Y1 - 2011

N2 - Social isolation (SI) of rats directly after weaning is a non-pharmacological, non-lesion animal model based on the neurodevelopmental hypothesis of schizophrenia. The model causes several neurobiological and behavioral alterations consistent with observations in schizophrenia.

AB - Social isolation (SI) of rats directly after weaning is a non-pharmacological, non-lesion animal model based on the neurodevelopmental hypothesis of schizophrenia. The model causes several neurobiological and behavioral alterations consistent with observations in schizophrenia.

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KW - Analysis of Variance

KW - Animals

KW - Animals, Newborn

KW - Antipsychotic Agents

KW - Behavior, Animal

KW - Cohort Studies

KW - Dose-Response Relationship, Drug

KW - Hyperkinesis

KW - Inhibition (Psychology)

KW - Male

KW - Motor Activity

KW - Psychoacoustics

KW - Random Allocation

KW - Rats

KW - Social Isolation

KW - Time Factors

U2 - 10.1007/s00213-010-2128-9

DO - 10.1007/s00213-010-2128-9

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