Phase behavior of pure lipid bilayers with mismatch interactions

Zhengping Zhang; Mohamed Laradji; Hong Guo; O. G. Mouritsen; M. J. Zuckermann

doi:10.1103/PhysRevA.45.7560

Phase behavior of pure lipid bilayers with mismatch interactions

Zhengping Zhang, Mohamed Laradji, Hong Guo, O. G. Mouritsen, M. J. Zuckermann

Research output: Contribution to journal › Journal article › Research › peer-review

26 Citations (Scopus)

Abstract

Recently Corvera, Laradji, and Zuckermann (unpublished) showed that the multistate lattice model due to Pink, Green, and Chapman [Biochemistry 20, 6692 (1981)] with parameters obtained from fitting to thermodynamic data for saturated phospholipid bilayers does not exhibit a phase transition but could instead be described in terms of short-range fluctuations close to a critical point. We have extended the Pink-Green-Chapman model by including hydrophobic mismatch interactions between the lipid acyl-chain conformational states. We used Monte Carlo techniques to examine the phase behavior of the extended model and found that it exhibits first-order phase transitions above a critical value of the mismatch parameter. The results are discussed in relation to previous theoretical work as well as experimental measurements on lipid bilayers.

Original language	English
Journal	Physical Review A - Atomic, Molecular, and Optical Physics
Volume	45
Issue number	10
Pages (from-to)	7560-7567
Number of pages	8
ISSN	2469-9926
DOIs	https://doi.org/10.1103/PhysRevA.45.7560
Publication status	Published - 1992
Externally published	Yes

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10.1103/PhysRevA.45.7560

Cite this

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title = "Phase behavior of pure lipid bilayers with mismatch interactions",

abstract = "Recently Corvera, Laradji, and Zuckermann (unpublished) showed that the multistate lattice model due to Pink, Green, and Chapman [Biochemistry 20, 6692 (1981)] with parameters obtained from fitting to thermodynamic data for saturated phospholipid bilayers does not exhibit a phase transition but could instead be described in terms of short-range fluctuations close to a critical point. We have extended the Pink-Green-Chapman model by including hydrophobic mismatch interactions between the lipid acyl-chain conformational states. We used Monte Carlo techniques to examine the phase behavior of the extended model and found that it exhibits first-order phase transitions above a critical value of the mismatch parameter. The results are discussed in relation to previous theoretical work as well as experimental measurements on lipid bilayers.",

author = "Zhengping Zhang and Mohamed Laradji and Hong Guo and Mouritsen, {O. G.} and Zuckermann, {M. J.}",

year = "1992",

doi = "10.1103/PhysRevA.45.7560",

language = "English",

volume = "45",

pages = "7560--7567",

journal = "Physical Review A - Atomic, Molecular, and Optical Physics",

issn = "1050-2947",

publisher = "American Physical Society",

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TY - JOUR

T1 - Phase behavior of pure lipid bilayers with mismatch interactions

AU - Zhang, Zhengping

AU - Laradji, Mohamed

AU - Guo, Hong

AU - Mouritsen, O. G.

AU - Zuckermann, M. J.

PY - 1992

Y1 - 1992

N2 - Recently Corvera, Laradji, and Zuckermann (unpublished) showed that the multistate lattice model due to Pink, Green, and Chapman [Biochemistry 20, 6692 (1981)] with parameters obtained from fitting to thermodynamic data for saturated phospholipid bilayers does not exhibit a phase transition but could instead be described in terms of short-range fluctuations close to a critical point. We have extended the Pink-Green-Chapman model by including hydrophobic mismatch interactions between the lipid acyl-chain conformational states. We used Monte Carlo techniques to examine the phase behavior of the extended model and found that it exhibits first-order phase transitions above a critical value of the mismatch parameter. The results are discussed in relation to previous theoretical work as well as experimental measurements on lipid bilayers.

AB - Recently Corvera, Laradji, and Zuckermann (unpublished) showed that the multistate lattice model due to Pink, Green, and Chapman [Biochemistry 20, 6692 (1981)] with parameters obtained from fitting to thermodynamic data for saturated phospholipid bilayers does not exhibit a phase transition but could instead be described in terms of short-range fluctuations close to a critical point. We have extended the Pink-Green-Chapman model by including hydrophobic mismatch interactions between the lipid acyl-chain conformational states. We used Monte Carlo techniques to examine the phase behavior of the extended model and found that it exhibits first-order phase transitions above a critical value of the mismatch parameter. The results are discussed in relation to previous theoretical work as well as experimental measurements on lipid bilayers.

U2 - 10.1103/PhysRevA.45.7560

DO - 10.1103/PhysRevA.45.7560

M3 - Journal article

AN - SCOPUS:0010935591

VL - 45

SP - 7560

EP - 7567

JO - Physical Review A - Atomic, Molecular, and Optical Physics

JF - Physical Review A - Atomic, Molecular, and Optical Physics

SN - 1050-2947

IS - 10

ER -