TY - JOUR
T1 - Phenotypic Characterization and Comparative Genomic Analysis of Novel Salmonella Bacteriophages Isolated from a Tropical Rainforest
AU - Mutusamy, Prasanna
AU - Singh, Kirnpal Kaur Banga
AU - Yin, Lee Su
AU - Petersen, Bent
AU - Sicheritz-Ponten, Thomas
AU - Clokie, Martha R. J.
AU - Loke, Stella
AU - Millard, Andrew
AU - Parimannan, Sivachandran
AU - Rajandas, Heera
PY - 2023
Y1 - 2023
N2 - Salmonella infections across the globe are becoming more challenging to control due to the emergence of multidrug-resistant (MDR) strains. Lytic phages may be suitable alternatives for treating these multidrug-resistant Salmonella infections. Most Salmonella phages to date were collected from human-impacted environments. To further explore the Salmonella phage space, and to potentially identify phages with novel characteristics, we characterized Salmonella-specific phages isolated from the Penang National Park, a conserved rainforest. Four phages with a broad lytic spectrum (kills >5 Salmonella serovars) were further characterized; they have isometric heads and cone-shaped tails, and genomes of similar to 39,900 bp, encoding 49 CDSs. As the genomes share a
AB - Salmonella infections across the globe are becoming more challenging to control due to the emergence of multidrug-resistant (MDR) strains. Lytic phages may be suitable alternatives for treating these multidrug-resistant Salmonella infections. Most Salmonella phages to date were collected from human-impacted environments. To further explore the Salmonella phage space, and to potentially identify phages with novel characteristics, we characterized Salmonella-specific phages isolated from the Penang National Park, a conserved rainforest. Four phages with a broad lytic spectrum (kills >5 Salmonella serovars) were further characterized; they have isometric heads and cone-shaped tails, and genomes of similar to 39,900 bp, encoding 49 CDSs. As the genomes share a
KW - Salmonella
KW - bacteriophages
KW - tropical rainforest
KW - comparative genomics
KW - HOST-RANGE
KW - RESISTANCE
KW - ALIGNMENT
U2 - 10.3390/ijms24043678
DO - 10.3390/ijms24043678
M3 - Journal article
C2 - 36835084
VL - 24
JO - International Journal of Molecular Sciences (Online)
JF - International Journal of Molecular Sciences (Online)
SN - 1661-6596
IS - 4
M1 - 3678
ER -