Physical activity, sedentary time, and sleep and the association with inflammatory markers and adiponectin in 8- to 11-year-old Danish children

Mette Søndergaard Nielsen, Jonas Salling Quist, Jean-Philippe Chaput, Stine-Mathilde Dalskov, Camilla Trab Damsgaard, Christian Ritz, Arne Astrup, Kim F. Michaelsen, Anders Mikael Sjödin, Mads Fiil Hjorth

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Abstract

BACKGROUND: Inflammatory markers, adiponectin, and movement/non-movement behaviors have all been linked to risk factors for cardiovascular disease; however, the association between childhood movement/non-movement behaviors and inflammatory markers and adiponectin is unknown.

METHODS: We explored the association between accelerometer determined moderate-to-vigorous physical activity (MVPA), sedentary time, and sleep (7 days/8 nights) and fasting C-reactive protein (CRP), interleukin-6 (IL-6), and adiponectin in 806 school children. A sleep variability score was calculated.

RESULTS: MVPA was negatively associated with adiponectin in boys and girls (P<0.001) and with CRP and IL-6 in girls (P<0.05) independent of sleep duration, sedentary time, age, fat mass index (FMI), and pubertal status. Sedentary time was positively associated with adiponectin in boys and girls (both P<0.001), and sleep duration with adiponectin in boys independent of age, FMI, and pubertal status (P<0.001); however, these associations disappeared after mutual adjustments for movement behavior. Sleep duration variability was positively associated with CRP in girls independent of all covariates (P<0.01).

CONCLUSION: MVPA remained negatively associated with inflammatory markers and adiponectin, and sleep duration variability positively associated with CRP after adjustment for FMI, pubertal status, and other movement behavior. The inverse association between MVPA and adiponectin conflicts with the anti-inflammatory properties of adiponectin.

Original languageEnglish
JournalJournal of Physical Activity & Health
Volume13
Issue number7
Pages (from-to)733-739
Number of pages7
ISSN1543-3080
DOIs
Publication statusPublished - 2016

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