Physician-defined severe toxicities occurring during and after cancer treatment: Modified consensus definitions and clinical applicability in the evaluation of cancer treatment

Camilla Grud Nielsen, Birthe Lykke Thomsen, Bodil Als-Nielsen, Rachel Conyers, Sima Jeha, Marion K. Mateos, Wojciech Mlynarski, Rob Pieters, Mathias Rathe, Kjeld Schmiegelow, Liv Andres-Jensen*, Ponte Legno Severe Toxicity

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Overall survival after cancer is increasing for the majority of cancer types, but survivors can be burdened lifelong by treatment-related severe toxicities. Integration of long-term toxicities in treatment evaluation is not least important for children and young adults with cancers with high survival probability. We present modified consensus definitions of 21 previously published physician-defined Severe Toxicities (STs), each reflecting the most serious long-term treatment-related toxicities and representing an unacceptable price for cure. Applying the Severe Toxicity (ST) concept to real-world data required careful adjustments of the original consensus definitions, translating them into standardized endpoints for evaluating treatment-related outcomes to ensure that (1) the STs can be classified uniformly and prospectively across different cohorts, and (2) the ST definitions allow for valid statistical analyses. The current paper presents the resulting modified consensus definitions of the 21 STs proposed to be included in outcome reporting of cancer treatment.

Original languageEnglish
Article number1155449
JournalFrontiers in Pediatrics
Volume11
Number of pages10
ISSN2296-2360
DOIs
Publication statusPublished - 2023

Keywords

  • cancer treatment
  • toxicities
  • childhood cancer
  • long-term
  • severe-toxicity-free-survival
  • COMPETING RISKS
  • CHILDHOOD
  • BURDEN

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