Plant P4-ATPase lipid flippases: How are they regulated?

Richard Villagrana; Rosa Laura López-Marqués

doi:10.1016/j.bbamcr.2023.119599

Plant P4-ATPase lipid flippases: How are they regulated?

Richard Villagrana, Rosa Laura López-Marqués^*

^*Corresponding author for this work

Section for Transport Biology

Research output: Contribution to journal › Review › Research › peer-review

2 Citations (Scopus)

6 Downloads (Pure)

Abstract

P4 ATPases are active membrane transporters that translocate lipids towards the cytosolic side of the biological membranes in eukaryotic cells. Due to their essential cellular functions, P4 ATPase activity is expected to be tightly controlled, but fundamental aspects of the regulation of plant P4 ATPases remain unstudied. In this mini-review, our knowledge of the regulatory mechanisms of yeast and mammalian P4 ATPases will be summarized, and sequence comparison and structural modelling will be used as a basis to discuss the putative regulation of the corresponding plant lipid transporters.

Original language	English
Article number	119599
Journal	Biochimica et Biophysica Acta - Molecular Cell Research
Volume	1871
Issue number	1
Number of pages	7
ISSN	0167-4889
DOIs	https://doi.org/10.1016/j.bbamcr.2023.119599
Publication status	Published - 2024

Bibliographical note

Funding Information:
Work in the López-Marqués lab is financed by the Novo Nordisk Foundation (Project number NNF19OC0056580/NovoCrops ), the Carlsberg Foundation (project number CF21-0389 ) and the Independent Research Fund Denmark | Nature and Universe (FNU, project number 1026-00024B ).

Publisher Copyright:
© 2023 The Author(s)

Keywords

Autoinhibition
Flippases
Kinase regulation
P4 ATPases
Structural modelling

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10.1016/j.bbamcr.2023.119599Licence: CC BY

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Cite this

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abstract = "P4 ATPases are active membrane transporters that translocate lipids towards the cytosolic side of the biological membranes in eukaryotic cells. Due to their essential cellular functions, P4 ATPase activity is expected to be tightly controlled, but fundamental aspects of the regulation of plant P4 ATPases remain unstudied. In this mini-review, our knowledge of the regulatory mechanisms of yeast and mammalian P4 ATPases will be summarized, and sequence comparison and structural modelling will be used as a basis to discuss the putative regulation of the corresponding plant lipid transporters.",

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N2 - P4 ATPases are active membrane transporters that translocate lipids towards the cytosolic side of the biological membranes in eukaryotic cells. Due to their essential cellular functions, P4 ATPase activity is expected to be tightly controlled, but fundamental aspects of the regulation of plant P4 ATPases remain unstudied. In this mini-review, our knowledge of the regulatory mechanisms of yeast and mammalian P4 ATPases will be summarized, and sequence comparison and structural modelling will be used as a basis to discuss the putative regulation of the corresponding plant lipid transporters.

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JO - B B A - Molecular Cell Research

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