TY - JOUR
T1 - Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals
AU - Wang, Fenglei
AU - Tessier, Anne Julie
AU - Liang, Liming
AU - Wittenbecher, Clemens
AU - Haslam, Danielle E.
AU - Fernández-Duval, Gonzalo
AU - Heather Eliassen, A.
AU - Rexrode, Kathryn M.
AU - Tobias, Deirdre K.
AU - Li, Jun
AU - Zeleznik, Oana
AU - Grodstein, Francine
AU - Martínez-González, Miguel A.
AU - Salas-Salvadó, Jordi
AU - Clish, Clary
AU - Lee, Kyu Ha
AU - Sun, Qi
AU - Stampfer, Meir J.
AU - Hu, Frank B.
AU - Guasch-Ferré, Marta
N1 - Publisher Copyright:
© 2023, Springer Nature Limited.
PY - 2023
Y1 - 2023
N2 - Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher levels of N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid, N1-acetylspermidine, and lipids with fewer double bonds are associated with increased risk of all-cause mortality and reduced odds of longevity; whereas L-serine and lipids with more double bonds are associated with lower mortality risk and a higher likelihood of longevity. We further develop a multi-metabolite profile score that is associated with higher mortality risk. Our findings suggest that differences in levels of nucleosides, amino acids, and several lipid subclasses can predict mortality. The underlying mechanisms remain to be determined.
AB - Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher levels of N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid, N1-acetylspermidine, and lipids with fewer double bonds are associated with increased risk of all-cause mortality and reduced odds of longevity; whereas L-serine and lipids with more double bonds are associated with lower mortality risk and a higher likelihood of longevity. We further develop a multi-metabolite profile score that is associated with higher mortality risk. Our findings suggest that differences in levels of nucleosides, amino acids, and several lipid subclasses can predict mortality. The underlying mechanisms remain to be determined.
U2 - 10.1038/s41467-023-41515-z
DO - 10.1038/s41467-023-41515-z
M3 - Journal article
C2 - 37717037
AN - SCOPUS:85171396312
VL - 14
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 5744
ER -