Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients

Morten Baltzer Houlind; Alberte Linnet Nielsen; Anne Byriel Walls; Louise Westberg Strejby Christensen; Rikke Lundsgaard Nielsen; Aino Andersen; Baker Nawfal Jawad; Ove Andersen; Morten Damgaard; Esben Iversen; Juliette Tavenier; Helle Gybel Juul-Larsen

doi:10.1111/bcpt.70002

Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients

Morten Baltzer Houlind^*, Alberte Linnet Nielsen, Anne Byriel Walls, Louise Westberg Strejby Christensen, Rikke Lundsgaard Nielsen, Aino Andersen, Baker Nawfal Jawad, Ove Andersen, Morten Damgaard, Esben Iversen, Juliette Tavenier, Helle Gybel Juul-Larsen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Accurate glomerular filtration rate (GFR) estimation is crucial for diagnosing kidney disease and prescribing renal risk medications [1-3]. In clinical practice, estimated GFR (eGFR) is typically determined by plasma creatinine levels adjusted for age and sex (eGFRcre) [4]. However, creatinine is an imperfect metric of GFR, particularly in older (age ≥ 65 years) hospitalized patients, due to age-related changes in non-GFR factors such as muscle mass and nutritional status that affect creatinine level [5]. The addition of cystatin C to creatinine (eGFRcomb) improves the accuracy of GFR estimates for older hospitalized patients, but there remains a large and unpredictable margin of error compared with measured GFR (mGFR)

Original language	English
Article number	e70002
Journal	Basic and Clinical Pharmacology and Toxicology
Volume	136
Issue number	3
Number of pages	3
ISSN	1742-7835
DOIs	https://doi.org/10.1111/bcpt.70002
Publication status	Published - 2025

Keywords

biomarkers
kidney/renal toxicology
pharmacokinetics
renal excretion of drugs
renal impairment and drug treatment
safety evaluation

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10.1111/bcpt.70002Licence: CC BY-NC-ND

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Cite this

Houlind, MB., Nielsen, AL., Walls, AB., Christensen, LWS., Nielsen, RL., Andersen, A., Jawad, BN., Andersen, O., Damgaard, M., Iversen, E., Tavenier, J., & Juul-Larsen, HG. (2025). Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients. Basic and Clinical Pharmacology and Toxicology, 136(3), Article e70002. https://doi.org/10.1111/bcpt.70002

Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients. / Houlind, Morten Baltzer; Nielsen, Alberte Linnet; Walls, Anne Byriel et al.
In: Basic and Clinical Pharmacology and Toxicology, Vol. 136, No. 3, e70002, 2025.

Research output: Contribution to journal › Journal article › Research › peer-review

Houlind, MB, Nielsen, AL, Walls, AB, Christensen, LWS, Nielsen, RL, Andersen, A, Jawad, BN, Andersen, O , Damgaard, M, Iversen, E, Tavenier, J & Juul-Larsen, HG 2025, 'Plasma NGAL, suPAR, KIM-1 and GDF-15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients', Basic and Clinical Pharmacology and Toxicology, vol. 136, no. 3, e70002. https://doi.org/10.1111/bcpt.70002

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