TY - JOUR
T1 - Plasma tissue inhibitor of metalloproteinases-1 as a biological marker? Pre-analytical considerations
AU - Lomholt, Anne Fog
AU - Frederiksen, Camilla
AU - Christensen, Ib Jarle
AU - Brünner, Nils
AU - Nielsen, Hans Jørgen
PY - 2007
Y1 - 2007
N2 - Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.
AB - Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) may be a valuable biological marker in Colorectal Cancer (CRC). However, prospective validation of TIMP-1 as a biological marker should include a series of pre-analytical considerations. TIMP-1 is stored in platelets, which may degranulate during collection and storage. The aim of this study was to evaluate the influence of platelet TIMP-1 contamination on plasma TIMP-1 levels in healthy volunteers.
U2 - http://dx.doi.org/10.1016/j.cca.2007.01.022
DO - http://dx.doi.org/10.1016/j.cca.2007.01.022
M3 - Journal article
VL - 380
SP - 128
EP - 132
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 1-2
ER -