Platform trials: Platformsforsøg

Anders Perner; Maj Brit N. Kjær; Hans Christian Thorsen-Meyer; Benjamin S. Kaas-Hansen; Marie W. Munch; Marie O. Collet; Camilla Rl Bruun; Aksel Kg Jensen; Theis Lange; Trine Albertsen; Claus Duedal Pedersen; Lone M. Poulsen; Ole Mathiesen; Anne C. Brøchner; Thomas Strøm; Lars W. Andersen; Steffen Christensen; Bodil S. Rasmussen; Olav L. Schjørring; Mathias Maagaard; Morten Hylander Møller; Anders Granholm

Platform trials: Platformsforsøg

Anders Perner, Maj Brit N. Kjær, Hans Christian Thorsen-Meyer, Benjamin S. Kaas-Hansen, Marie W. Munch, Marie O. Collet, Camilla Rl Bruun, Aksel Kg Jensen, Theis Lange, Trine Albertsen, Claus Duedal Pedersen, Lone M. Poulsen, Ole Mathiesen, Anne C. Brøchner, Thomas Strøm, Lars W. Andersen, Steffen Christensen, Bodil S. Rasmussen, Olav L. Schjørring, Mathias MaagaardMorten Hylander Møller, Anders Granholm

Research output: Contribution to journal › Review › peer-review

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Abstract

Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.

Original language	English
Journal	Ugeskrift for Laeger
Volume	185
Issue number	41
Number of pages	10
ISSN	0041-5782
Publication status	Published - 2023

Bibliographical note

Publisher Copyright:
Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

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FulltextFinal published version, 816 KBLicence: CC BY

https://ugeskriftet.dk/videnskab/platformsforsogLicence: CC BY

Cite this

Perner, A., Kjær, M. B. N., Thorsen-Meyer, H. C., Kaas-Hansen, B. S., Munch, M. W., Collet, M. O., Bruun, C. R., Jensen, A. K., Lange, T., Albertsen, T., Pedersen, C. D., Poulsen, L. M., Mathiesen, O., Brøchner, A. C., Strøm, T., Andersen, L. W., Christensen, S., Rasmussen, B. S., Schjørring, O. L., ... Granholm, A. (2023). Platform trials: Platformsforsøg. Ugeskrift for Laeger, 185(41). https://ugeskriftet.dk/videnskab/platformsforsog

Perner, A, Kjær, MBN, Thorsen-Meyer, HC, Kaas-Hansen, BS, Munch, MW, Collet, MO, Bruun, CR, Jensen, AK , Lange, T, Albertsen, T, Pedersen, CD, Poulsen, LM, Mathiesen, O, Brøchner, AC, Strøm, T, Andersen, LW, Christensen, S, Rasmussen, BS, Schjørring, OL, Maagaard, M, Møller, MH & Granholm, A 2023, 'Platform trials: Platformsforsøg', Ugeskrift for Laeger, vol. 185, no. 41. <https://ugeskriftet.dk/videnskab/platformsforsog>

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abstract = "Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.",

author = "Anders Perner and Kj{\ae}r, {Maj Brit N.} and Thorsen-Meyer, {Hans Christian} and Kaas-Hansen, {Benjamin S.} and Munch, {Marie W.} and Collet, {Marie O.} and Bruun, {Camilla Rl} and Jensen, {Aksel Kg} and Theis Lange and Trine Albertsen and Pedersen, {Claus Duedal} and Poulsen, {Lone M.} and Ole Mathiesen and Br{\o}chner, {Anne C.} and Thomas Str{\o}m and Andersen, {Lars W.} and Steffen Christensen and Rasmussen, {Bodil S.} and Schj{\o}rring, {Olav L.} and Mathias Maagaard and M{\o}ller, {Morten Hylander} and Anders Granholm",

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year = "2023",

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T2 - Platformsforsøg

AU - Perner, Anders

AU - Kjær, Maj Brit N.

AU - Thorsen-Meyer, Hans Christian

AU - Kaas-Hansen, Benjamin S.

AU - Munch, Marie W.

AU - Collet, Marie O.

AU - Bruun, Camilla Rl

AU - Jensen, Aksel Kg

AU - Lange, Theis

AU - Albertsen, Trine

AU - Pedersen, Claus Duedal

AU - Poulsen, Lone M.

AU - Mathiesen, Ole

AU - Brøchner, Anne C.

AU - Strøm, Thomas

AU - Andersen, Lars W.

AU - Christensen, Steffen

AU - Rasmussen, Bodil S.

AU - Schjørring, Olav L.

AU - Maagaard, Mathias

AU - Møller, Morten Hylander

AU - Granholm, Anders

N1 - Publisher Copyright: Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2023

Y1 - 2023

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AB - Platform trials focus on the perpetual testing of many interventions in a disease or a setting. These trials have lasting organizational, administrative, data, analytic, and operational frameworks making them highly efficient. The use of adaptation often increases the probabilities of allocating participants to better interventions and obtaining conclusive results. The COVID-19 pandemic showed the potential of platform trials as a fast and valid way to improved treatments. This review gives an overview of key concepts and elements using the Intensive Care Platform Trial (INCEPT) as an example.

M3 - Review

C2 - 37873986

AN - SCOPUS:85175661699

SN - 0041-5782

VL - 185

JO - Ugeskrift for Laeger

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ER -