Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

Huda S Darusman; Jacub Pandelaki; Rahmad Mulyadi; Dondin Sajuthi; Indah A Putri; Otto H Kalliokoski; Josep Call; Klas S P Abelson; Steve Schapiro; Albert Gjedde; Jann Hau

Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

Huda S Darusman, Jacub Pandelaki, Rahmad Mulyadi, Dondin Sajuthi, Indah A Putri, Otto H Kalliokoski, Josep Call, Klas S P Abelson, Steve Schapiro, Albert Gjedde, Jann Hau

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

Abstract

BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.

MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.

RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.

CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.

Original language	English
Journal	In Vivo
Volume	28
Issue number	2
Pages (from-to)	173-84
Number of pages	12
ISSN	0258-851X
Publication status	Published - 19 Mar 2014

Access to Document

http://iv.iiarjournals.org/content/28/2/173.long

Cite this

Darusman, H. S., Pandelaki, J., Mulyadi, R., Sajuthi, D., Putri, I. A., Kalliokoski, O. H., Call, J., Abelson, K. S. P., Schapiro, S., Gjedde, A., & Hau, J. (2014). Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid. In Vivo, 28(2), 173-84. http://iv.iiarjournals.org/content/28/2/173.long

Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid. / Darusman, Huda S; Pandelaki, Jacub; Mulyadi, Rahmad; Sajuthi, Dondin; Putri, Indah A; Kalliokoski, Otto H; Call, Josep; Abelson, Klas S P; Schapiro, Steve; Gjedde, Albert ; Hau, Jann.

In: In Vivo, Vol. 28, No. 2, 19.03.2014, p. 173-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Darusman, HS, Pandelaki, J, Mulyadi, R, Sajuthi, D, Putri, IA, Kalliokoski, OH, Call, J, Abelson, KSP, Schapiro, S, Gjedde, A & Hau, J 2014, 'Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid', In Vivo, vol. 28, no. 2, pp. 173-84. <http://iv.iiarjournals.org/content/28/2/173.long>

Darusman, Huda S ; Pandelaki, Jacub ; Mulyadi, Rahmad ; Sajuthi, Dondin ; Putri, Indah A ; Kalliokoski, Otto H ; Call, Josep ; Abelson, Klas S P ; Schapiro, Steve ; Gjedde, Albert ; Hau, Jann. / Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid. In: In Vivo. 2014 ; Vol. 28, No. 2. pp. 173-84.

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title = "Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid",

abstract = "BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.",

author = "Darusman, {Huda S} and Jacub Pandelaki and Rahmad Mulyadi and Dondin Sajuthi and Putri, {Indah A} and Kalliokoski, {Otto H} and Josep Call and Abelson, {Klas S P} and Steve Schapiro and Albert Gjedde and Jann Hau",

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T1 - Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal Fluid

AU - Darusman, Huda S

AU - Pandelaki, Jacub

AU - Mulyadi, Rahmad

AU - Sajuthi, Dondin

AU - Putri, Indah A

AU - Kalliokoski, Otto H

AU - Call, Josep

AU - Abelson, Klas S P

AU - Schapiro, Steve

AU - Gjedde, Albert

AU - Hau, Jann

PY - 2014/3/19

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N2 - BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.

AB - BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.

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SN - 0258-851X

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