Possible site of action of CGRP antagonists in migraine

Peer Tfelt-Hansen; Jes Olesen

doi:http://dx.doi.org/10.1177/0333102411398403

Possible site of action of CGRP antagonists in migraine

Peer Tfelt-Hansen, Jes Olesen

Research output: Contribution to journal › Review › Research › peer-review

41 Citations (Scopus)

Abstract

The calcitonin gene-related peptide (CGRP) receptor antagonists olcegepant and telcagepant are very potent drugs. Both are effective in migraine but in doses much higher than would be predicted from receptor binding and other in vitro results. This could perhaps suggest an effect of CGRP antagonists behind the blood-brain barrier (BBB), i.e. in the central nervous system (CNS).

Original language	English
Journal	Cephalalgia
Volume	31
Issue number	6
Pages (from-to)	748-50
Number of pages	3
ISSN	0333-1024
DOIs	https://doi.org/10.1177/0333102411398403
Publication status	Published - 2011

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http://dx.doi.org/10.1177/0333102411398403

Cite this

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abstract = "The calcitonin gene-related peptide (CGRP) receptor antagonists olcegepant and telcagepant are very potent drugs. Both are effective in migraine but in doses much higher than would be predicted from receptor binding and other in vitro results. This could perhaps suggest an effect of CGRP antagonists behind the blood-brain barrier (BBB), i.e. in the central nervous system (CNS).",

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AB - The calcitonin gene-related peptide (CGRP) receptor antagonists olcegepant and telcagepant are very potent drugs. Both are effective in migraine but in doses much higher than would be predicted from receptor binding and other in vitro results. This could perhaps suggest an effect of CGRP antagonists behind the blood-brain barrier (BBB), i.e. in the central nervous system (CNS).

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DO - http://dx.doi.org/10.1177/0333102411398403

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