Posture changes platelet inhibition time after ingestion of prasugrel

Jacob Antonsen, Nina Bundgaard, Lene Holmvang, Thomas Engstrøm, Kasper Iversen

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Abstract

INTRODUCTION: Several studies have suggested that supine posture during pill ingestion prolongs oesophageal transit time. Whether ingesting prasugrel in an upright position leads to reduced platelet reactivity during percutaneous coronary intervention remains unclear.

METHODS: A total of 20 people were randomly assigned to ingest 60 mg of prasugrel in either the supine or upright position. Platelet reactivity was analysed using the point-of-care assay VerifyNow.

RESULTS: In the upright position, the velocity of platelet inhibition was highest between 20 and 40 min. (Δ = 101.9 P2Y12 reaction units (PRU)). In the supine position, the highest value was seen between 40 and 60 min. (Δ = 56.85 PRU). Time to reach the cut-off for reducing peri- and post-operative risk of thrombosis showed a mean difference of 8 min. in favour of the upright group.

CONCLUSIONS: A trend towards faster reduction of platelet reactivity was seen when ingesting prasugrel in the upright position compared with the supine position.

FUNDING: This work was supported by Oda and Hans Svenningsens Foundation (grant number: BOF-10109). The foundation had no part in the collection, analysis or interpretation of data, or in the writing of the report or the decision to submit the work for publication.

TRIAL REGISTRATION: This trial was registered with clinicaltrials.gov (NCT01365741).

Original languageEnglish
Article numberA5504
JournalDanish Medical Journal
Volume65
Issue number10
ISSN1603-9629
Publication statusPublished - 2018

Keywords

  • Administration, Oral
  • Adult
  • Blood Platelets/drug effects
  • Cross-Over Studies
  • Humans
  • Male
  • Platelet Aggregation Inhibitors/administration & dosage
  • Prasugrel Hydrochloride/administration & dosage
  • Standing Position
  • Supine Position
  • Time Factors
  • Young Adult

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