Potential Retinal Biomarkers in Alzheimer's Disease

Mariana Yolotzin Garcia Bermudez; Rupali Vohra; Kristine Freude; Peter van Wijngaarden; Keith K. Martin; Maj Schneider Thomsen; Blanca Aldana; Miriam Kolko

doi:10.3390/ijms242115834

Potential Retinal Biomarkers in Alzheimer's Disease

Mariana Yolotzin Garcia Bermudez, Rupali Vohra, Kristine Freude, Peter van Wijngaarden, Keith K. Martin, Maj Schneider Thomsen, Blanca Aldana, Miriam Kolko^*

^*Corresponding author for this work

Research output: Contribution to journal › Review › peer-review

6 Citations (Scopus)

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Abstract

Alzheimer’s disease (AD) represents a major diagnostic challenge, as early detection is crucial for effective intervention. This review examines the diagnostic challenges facing current AD evaluations and explores the emerging field of retinal alterations as early indicators. Recognizing the potential of the retina as a noninvasive window to the brain, we emphasize the importance of identifying retinal biomarkers in the early stages of AD. However, the examination of AD is not without its challenges, as the similarities shared with other retinal diseases introduce complexity in the search for AD-specific markers. In this review, we address the relevance of using the retina for the early diagnosis of AD and the complex challenges associated with the search for AD-specific retinal biomarkers. We provide a comprehensive overview of the current landscape and highlight avenues for progress in AD diagnosis by retinal examination.

Original language	English
Article number	15834
Journal	International Journal of Molecular Sciences (Online)
Volume	24
Issue number	21
Number of pages	26
ISSN	1661-6596
DOIs	https://doi.org/10.3390/ijms242115834
Publication status	Published - 2023

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Cite this

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title = "Potential Retinal Biomarkers in Alzheimer's Disease",

abstract = "Alzheimer{\textquoteright}s disease (AD) represents a major diagnostic challenge, as early detection is crucial for effective intervention. This review examines the diagnostic challenges facing current AD evaluations and explores the emerging field of retinal alterations as early indicators. Recognizing the potential of the retina as a noninvasive window to the brain, we emphasize the importance of identifying retinal biomarkers in the early stages of AD. However, the examination of AD is not without its challenges, as the similarities shared with other retinal diseases introduce complexity in the search for AD-specific markers. In this review, we address the relevance of using the retina for the early diagnosis of AD and the complex challenges associated with the search for AD-specific retinal biomarkers. We provide a comprehensive overview of the current landscape and highlight avenues for progress in AD diagnosis by retinal examination.",

author = "{Garcia Bermudez}, {Mariana Yolotzin} and Rupali Vohra and Kristine Freude and {van Wijngaarden}, Peter and Martin, {Keith K.} and Thomsen, {Maj Schneider} and Blanca Aldana and Miriam Kolko",

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AU - Garcia Bermudez, Mariana Yolotzin

AU - Vohra, Rupali

AU - Freude, Kristine

AU - van Wijngaarden, Peter

AU - Martin, Keith K.

AU - Thomsen, Maj Schneider

AU - Aldana, Blanca

AU - Kolko, Miriam

PY - 2023

Y1 - 2023

N2 - Alzheimer’s disease (AD) represents a major diagnostic challenge, as early detection is crucial for effective intervention. This review examines the diagnostic challenges facing current AD evaluations and explores the emerging field of retinal alterations as early indicators. Recognizing the potential of the retina as a noninvasive window to the brain, we emphasize the importance of identifying retinal biomarkers in the early stages of AD. However, the examination of AD is not without its challenges, as the similarities shared with other retinal diseases introduce complexity in the search for AD-specific markers. In this review, we address the relevance of using the retina for the early diagnosis of AD and the complex challenges associated with the search for AD-specific retinal biomarkers. We provide a comprehensive overview of the current landscape and highlight avenues for progress in AD diagnosis by retinal examination.

AB - Alzheimer’s disease (AD) represents a major diagnostic challenge, as early detection is crucial for effective intervention. This review examines the diagnostic challenges facing current AD evaluations and explores the emerging field of retinal alterations as early indicators. Recognizing the potential of the retina as a noninvasive window to the brain, we emphasize the importance of identifying retinal biomarkers in the early stages of AD. However, the examination of AD is not without its challenges, as the similarities shared with other retinal diseases introduce complexity in the search for AD-specific markers. In this review, we address the relevance of using the retina for the early diagnosis of AD and the complex challenges associated with the search for AD-specific retinal biomarkers. We provide a comprehensive overview of the current landscape and highlight avenues for progress in AD diagnosis by retinal examination.

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