Precursors of age-related macular degeneration: associations with vitamin A and interaction with CFHY402H in the Inter99 Eye Study

Inger Christine Munch, Ulla Toft, Allan Linneberg, Michael Larsen

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5 Citations (Scopus)

Abstract

PURPOSE: To investigate associations of very early age-related macular degeneration (AMD) with daily intake of vitamin A, beta-carotene, vitamin E, vitamin C, zinc and copper and interactions with AMD-associated polymorphisms in complement factor H (CFHY402H) and ARMS2/LOC387715.

METHODS: Cross-sectional study of 848 subjects aged 30-60 years from the Inter99 Eye Study. Daily intake of vitamins and minerals was estimated from a 198-item food frequency questionnaire. Digital fundus photographs were recorded in red-free illumination and graded for macular drusen >63 μm and numerous (>20) small hard macular drusen as a mean of both eyes.

RESULTS: Higher intake of vitamin A increased the risk of having macular drusen >63 μm with odds ratio = 1.82 (CI95 1.02-3.24, p = 0.042) comparing participants in the highest quartile of vitamin A intake with participants in the lowest quartile, adjusted for recruitment group, age and sex. There was a significant interaction with CFHY402H (p = 0.038). Among 504 participants with CFHY402H, the relative risk of having macular drusen >63 μm was increased in participants in the highest quartile of vitamin A intake (odds ratio = 2.58; CI95 1.16-5.73, p = 0.020) and in the second highest quartile (odds ratio = 3.27; CI95 1.50-7.13, p = 0.0029) compared with the lowest quartile. Further adjusting for total fat intake, energy intake, plasma cholesterol, body mass index (BMI), smoking, alcohol intake, education and physical activity strengthened the association.

CONCLUSIONS: In this cross-sectional study, a higher intake of vitamin A increased the risk of macular drusen >63 μm in subjects with CFHY402H. The study supports that vitamin A may be a risk factor for early AMD.

Original languageEnglish
JournalActa Ophthalmologica
Volume94
Issue number7
Pages (from-to)657-662
Number of pages6
ISSN1755-375X
DOIs
Publication statusPublished - Nov 2016

Keywords

  • Adult
  • Complement Factor H
  • Cross-Sectional Studies
  • Diet
  • Female
  • Humans
  • Macular Degeneration
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Proteins
  • Retinal Drusen
  • Risk Factors
  • Visual Acuity
  • Vitamin A
  • Vitamins
  • Journal Article
  • Randomized Controlled Trial

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