Preparation of Spirocyclic β-Proline Esters: Geometrically Restricted Building Blocks for Medicinal Chemistry

Kasper Fjelbye; Mauro Marigo; Rasmus Prætorius Clausen; Karsten Juhl

doi:10.1055/s-0036-1588902

Preparation of Spirocyclic β-Proline Esters: Geometrically Restricted Building Blocks for Medicinal Chemistry

Kasper Fjelbye
, Mauro Marigo
, Rasmus Prætorius Clausen
, Karsten Juhl^*

^*Corresponding author for this work

Medicinal Chemistry Research

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A series of novel N-Bn-protected spirocyclic β-proline esters were prepared using [3+2] cycloaddition and subsequently converted into their corresponding aldehydes. In addition, two novel N-Cbz-protected spirocyclic β-proline esters were prepared using intramolecular cyclization starting from simple precursors.

Original language	English
Article number	st-2016-b0534-l
Journal	SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
Volume	28
Issue number	2
Pages (from-to)	231-234
Number of pages	4
ISSN	0936-5214
DOIs	https://doi.org/10.1055/s-0036-1588902
Publication status	Published - 2017

Keywords

1,3-dipolar cycloaddition
intramolecular cyclization
oxetanes
spirocycles
β-proline esters

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10.1055/s-0036-1588902

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Cite this

Preparation of Spirocyclic β-Proline Esters: Geometrically Restricted Building Blocks for Medicinal Chemistry. / Fjelbye, Kasper; Marigo, Mauro; Clausen, Rasmus Prætorius et al.
In: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis, Vol. 28, No. 2, st-2016-b0534-l, 2017, p. 231-234.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "A series of novel N-Bn-protected spirocyclic β-proline esters were prepared using [3+2] cycloaddition and subsequently converted into their corresponding aldehydes. In addition, two novel N-Cbz-protected spirocyclic β-proline esters were prepared using intramolecular cyclization starting from simple precursors.",

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