Abstract
In humans, detection of autoantibodies (ABs) are used to diagnose and differentiate forms of autoimmune encephalitis (AE), and to determine the antigen location as either intra- or extracellular. Intracellular antigens are generally associated with a worse prognosis and a possible underlying neoplastic disease presumably triggering the improper immune response. Here, we describe the discovery of ABs targeting tripartite motif-containing protein 46 (TRIM46) in a dog with a clinical diagnosis of meningoencephalomyelitis of unknown origin (MUO). ABs were discovered using a tissue-based indirect immunofluorescence assay (IIF) and confirmed using a cell-based IIF assay. This is the first case of an intracellular neuronal antigen being targeted by ABs in a dog. In humans, anti-TRIM46-ABs have been reported in relation to paraneoplastic AE, with similar clinical and paraclinical presentation as the current case.
Original language | English |
---|---|
Publication date | 2024 |
Number of pages | 1 |
Publication status | Published - 2024 |
Event | 36th ESVN-ECVN Annual Symposium : Neuro-Opthalmology - Alfandega do Porto Congress Center, Porto, Portugal Duration: 13 Sep 2024 → 14 Sep 2024 https://www.ecvnporto2024.org/ |
Conference
Conference | 36th ESVN-ECVN Annual Symposium |
---|---|
Location | Alfandega do Porto Congress Center |
Country/Territory | Portugal |
City | Porto |
Period | 13/09/2024 → 14/09/2024 |
Internet address |