Presence of anti-TRIM46-autoantibodies in serum and cerebrospinal fluid from a dog presenting with meningoencephalomyelitis of unknown origin

Pernille Lindholm Heidemann, Anna Christine Nillson, Sandra Gaedt Schmidt , Hanne Birgit Gredal, Morten Blaabjerg

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Abstract

In humans, detection of autoantibodies (ABs) are used to diagnose and differentiate forms of autoimmune encephalitis (AE), and to determine the antigen location as either intra- or extracellular. Intracellular antigens are generally associated with a worse prognosis and a possible underlying neoplastic disease presumably triggering the improper immune response. Here, we describe the discovery of ABs targeting tripartite motif-containing protein 46 (TRIM46) in a dog with a clinical diagnosis of meningoencephalomyelitis of unknown origin (MUO). ABs were discovered using a tissue-based indirect immunofluorescence assay (IIF) and confirmed using a cell-based IIF assay. This is the first case of an intracellular neuronal antigen being targeted by ABs in a dog. In humans, anti-TRIM46-ABs have been reported in relation to paraneoplastic AE, with similar clinical and paraclinical presentation as the current case.
Original languageEnglish
Publication date2024
Number of pages1
Publication statusPublished - 2024
Event36th ESVN-ECVN Annual Symposium : Neuro-Opthalmology - Alfandega do Porto Congress Center, Porto, Portugal
Duration: 13 Sep 202414 Sep 2024
https://www.ecvnporto2024.org/

Conference

Conference36th ESVN-ECVN Annual Symposium
LocationAlfandega do Porto Congress Center
Country/TerritoryPortugal
CityPorto
Period13/09/202414/09/2024
Internet address

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