Process for the manufacture of ajoene derivatives

Thomas Bjarnsholt (Inventor), Niels Hoeiby, (Inventor), Peter Østrup Jensen (Inventor), Richard Phipps (Inventor), Sundaram Shanmugham, Meenakshi (Inventor), Maria Alhede (Inventor), Louise Dahl Hultqvist (Inventor), Tim Holm Jakobsen (Inventor), David Tanner (Inventor), Ostenfeld Larsen, Thomas (Inventor), Michael Givskov, (Inventor)

    Research output: Patent

    Abstract

    The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.

    Original languageEnglish
    IPCC07C 323/ 65 A I
    Patent numberWO2012076016
    Country/TerritoryDenmark
    Priority date08/12/2010
    Priority numberEP20100194154
    Publication statusPublished - 14 Jun 2012

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